A robustness analysis of eukaryotic cell cycle concerning Cdc25 and weel proteins

Takehito Azuma, Hisao Moriya, Hayato Matsumuro, Hiroaki Kitano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Weel proteins. The robustness of the eukaryotic cell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that Cdc2 and Cyclin proteins have main roles for eukaryotic cell cycle in this model but the robustness is not high against perturbation on its parameters. By introducing Cdc25 and Weel proteins to the mathematical model, it was verified by the sensitivity analysis that the modified has higher level of robustnesses than the original model does. Numerical examples are shown to demonstrate the original model and the modified model have almost identical cell cycle behaviors leaving robustness as a salient difference.

Original languageEnglish
Title of host publicationProceedings of the IEEE International Conference on Control Applications
Pages1734-1739
Number of pages6
DOIs
Publication statusPublished - 2007
Externally publishedYes
EventJoint 2006 IEEE Conference on Control Applications (CCA), Computer-Aided Control Systems Design Symposium (CACSD) and International Symposium on Intelligent Control (ISIC) - Munich, Germany
Duration: Oct 4 2006Oct 6 2006

Other

OtherJoint 2006 IEEE Conference on Control Applications (CCA), Computer-Aided Control Systems Design Symposium (CACSD) and International Symposium on Intelligent Control (ISIC)
CountryGermany
CityMunich
Period10/4/0610/6/06

Fingerprint

Cells
Proteins
Sensitivity analysis
Mathematical models

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Azuma, T., Moriya, H., Matsumuro, H., & Kitano, H. (2007). A robustness analysis of eukaryotic cell cycle concerning Cdc25 and weel proteins. In Proceedings of the IEEE International Conference on Control Applications (pp. 1734-1739). [4067418] https://doi.org/10.1109/CCA.2006.286135

A robustness analysis of eukaryotic cell cycle concerning Cdc25 and weel proteins. / Azuma, Takehito; Moriya, Hisao; Matsumuro, Hayato; Kitano, Hiroaki.

Proceedings of the IEEE International Conference on Control Applications. 2007. p. 1734-1739 4067418.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Azuma, T, Moriya, H, Matsumuro, H & Kitano, H 2007, A robustness analysis of eukaryotic cell cycle concerning Cdc25 and weel proteins. in Proceedings of the IEEE International Conference on Control Applications., 4067418, pp. 1734-1739, Joint 2006 IEEE Conference on Control Applications (CCA), Computer-Aided Control Systems Design Symposium (CACSD) and International Symposium on Intelligent Control (ISIC), Munich, Germany, 10/4/06. https://doi.org/10.1109/CCA.2006.286135
Azuma T, Moriya H, Matsumuro H, Kitano H. A robustness analysis of eukaryotic cell cycle concerning Cdc25 and weel proteins. In Proceedings of the IEEE International Conference on Control Applications. 2007. p. 1734-1739. 4067418 https://doi.org/10.1109/CCA.2006.286135
Azuma, Takehito ; Moriya, Hisao ; Matsumuro, Hayato ; Kitano, Hiroaki. / A robustness analysis of eukaryotic cell cycle concerning Cdc25 and weel proteins. Proceedings of the IEEE International Conference on Control Applications. 2007. pp. 1734-1739
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