A repetitive, steady mouth opening induced an osteoarthritis-like lesion in the rabbit temporomandibular joint

T. Fujisawa, Takuo Kuboki, T. Kasai, W. Sonoyama, S. Kojima, J. Uehara, C. Komori, H. Yatani, Takako Hattori, Masaharu Takigawa

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Although excessive mechanical stress is assumed to be one of the factors contributing to pathogenesis of temporomandibular joint (TMJ) osteoarthritis (OA), no pure mechanical-stress-induced OA model has been developed without surgical manipulation or puncture of the joint cavity. The purpose of this study was to establish a genuine mechanical-stress-induced OA model of the rabbit TMJ. In the experimental rabbits, repetitive, forced jaw-opening, 3 hrs/day for 5 days, was applied with the use of a general anesthesia protocol. By histological assessment of the TMJ articular tissues, partial eburnation of the articular cartilage, reactive marginal proliferation of the articular cartilage chondrocytes, and nested proliferation of chondrocytes in the subchondral bone area were observed at 7 days after the repetitive, forced-jaw-opening period. These results suggest that the repetitive, forced-jaw-opening protocol without surgical intervention can induce evident OA-like lesions in the rabbit TMJ, and this OA model may greatly contribute to the elucidation of the cartilage degradation mechanism in TMJ OA.

Original languageEnglish
Pages (from-to)731-735
Number of pages5
JournalJournal of Dental Research
Volume82
Issue number9
Publication statusPublished - Sep 2003

Fingerprint

Temporomandibular Joint
Osteoarthritis
Mouth
Rabbits
Mechanical Stress
Jaw
Articular Cartilage
Chondrocytes
Joints
Punctures
General Anesthesia
Cartilage
Bone and Bones

Keywords

  • Articular cartilage
  • Mechanical stress
  • Osteoarthritis
  • Temporomandibular joint

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

A repetitive, steady mouth opening induced an osteoarthritis-like lesion in the rabbit temporomandibular joint. / Fujisawa, T.; Kuboki, Takuo; Kasai, T.; Sonoyama, W.; Kojima, S.; Uehara, J.; Komori, C.; Yatani, H.; Hattori, Takako; Takigawa, Masaharu.

In: Journal of Dental Research, Vol. 82, No. 9, 09.2003, p. 731-735.

Research output: Contribution to journalArticle

Fujisawa, T, Kuboki, T, Kasai, T, Sonoyama, W, Kojima, S, Uehara, J, Komori, C, Yatani, H, Hattori, T & Takigawa, M 2003, 'A repetitive, steady mouth opening induced an osteoarthritis-like lesion in the rabbit temporomandibular joint', Journal of Dental Research, vol. 82, no. 9, pp. 731-735.
Fujisawa, T. ; Kuboki, Takuo ; Kasai, T. ; Sonoyama, W. ; Kojima, S. ; Uehara, J. ; Komori, C. ; Yatani, H. ; Hattori, Takako ; Takigawa, Masaharu. / A repetitive, steady mouth opening induced an osteoarthritis-like lesion in the rabbit temporomandibular joint. In: Journal of Dental Research. 2003 ; Vol. 82, No. 9. pp. 731-735.
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