A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging

Teruaki Toyota, Tadashi Hanafusa, Takashi Oda, Iwane Koumura, Takanori Sasaki, Eiji Matsuura, Hiromi Kumon, Tsuneo Yano, Toshiro Ono

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume298
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • Anion exchange chromatography
  • Atomic absorption spectrometry
  • Cu
  • Cyclotron
  • Positron emission tomography (PET)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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