A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging

Teruaki Toyota, Tadashi Hanafusa, Takashi Oda, Iwane Koumura, Takanori Sasaki, Eiji Matsuura, Hiromi Kumon, Tsuneo Yano, Toshiro Ono

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume298
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Anion Exchange Resins
Cyclotrons
Radiopharmaceuticals
Ion Exchange
Antibodies
Positron-Emission Tomography
Purification
Monoclonal Antibodies
Imaging techniques
Ion exchange
Positron emission tomography
Monoclonal antibodies
Labeling
Negative ions
Resins
Impurities

Keywords

  • Cu
  • Anion exchange chromatography
  • Atomic absorption spectrometry
  • Cyclotron
  • Positron emission tomography (PET)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Pollution
  • Health, Toxicology and Mutagenesis
  • Nuclear Energy and Engineering
  • Analytical Chemistry

Cite this

A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging. / Toyota, Teruaki; Hanafusa, Tadashi; Oda, Takashi; Koumura, Iwane; Sasaki, Takanori; Matsuura, Eiji; Kumon, Hiromi; Yano, Tsuneo; Ono, Toshiro.

In: Journal of Radioanalytical and Nuclear Chemistry, Vol. 298, No. 1, 2013, p. 295-300.

Research output: Contribution to journalArticle

@article{01e21e2a282641928f6395926949206c,
title = "A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging",
abstract = "Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.",
keywords = "Cu, Anion exchange chromatography, Atomic absorption spectrometry, Cyclotron, Positron emission tomography (PET)",
author = "Teruaki Toyota and Tadashi Hanafusa and Takashi Oda and Iwane Koumura and Takanori Sasaki and Eiji Matsuura and Hiromi Kumon and Tsuneo Yano and Toshiro Ono",
year = "2013",
doi = "10.1007/s10967-012-2340-7",
language = "English",
volume = "298",
pages = "295--300",
journal = "Journal of Radioanalytical Chemistry",
issn = "0022-4081",
publisher = "Springer Netherlands",
number = "1",

}

TY - JOUR

T1 - A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging

AU - Toyota, Teruaki

AU - Hanafusa, Tadashi

AU - Oda, Takashi

AU - Koumura, Iwane

AU - Sasaki, Takanori

AU - Matsuura, Eiji

AU - Kumon, Hiromi

AU - Yano, Tsuneo

AU - Ono, Toshiro

PY - 2013

Y1 - 2013

N2 - Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.

AB - Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.

KW - Cu

KW - Anion exchange chromatography

KW - Atomic absorption spectrometry

KW - Cyclotron

KW - Positron emission tomography (PET)

UR - http://www.scopus.com/inward/record.url?scp=84885188844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885188844&partnerID=8YFLogxK

U2 - 10.1007/s10967-012-2340-7

DO - 10.1007/s10967-012-2340-7

M3 - Article

VL - 298

SP - 295

EP - 300

JO - Journal of Radioanalytical Chemistry

JF - Journal of Radioanalytical Chemistry

SN - 0022-4081

IS - 1

ER -