Abstract
Background/Aims: Few studies exist on the efficacy and long-term outcome of radiation therapy (RT) for gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Methods: Twenty-two patients with stage I or stage II1 disease were prospectively evaluated, including 14 patients without Helicobacter pylori(H. pylori) infection and 8 patients with persistent lymphoma after H. pylori eradication. RT dose was 30 Gy in daily fractions of 1.5 Gy. All patients underwent endoscopic and histological follow-up regularly. Results: The study included 22 patients with a mean age of 63 years. The t(11;18)(q21;q21) translocation occurred in 8 of the 22 cases. All patients showed complete remission without any serious toxicity. At a median follow-up evaluation 74 months (range 27-159) after completion of RT, the overall and relapse-free survival rates after 5 years were 91 and 84%, respectively. Although no patient showed local recurrence of lymphoma, distant recurrence was detected in 3 patients, all of whom were H. pylori negative; MALT lymphoma relapsed in two patients with the t(11;18)(q21;q21) translocation, and diffuse large-cell lymphoma developed in one patient without the translocation. Conclusion: RT provides excellent local control of the gastric MALT lymphoma. However, continuous follow-up is mandatory as relapse may occur in other sites.
| Original language | English |
|---|---|
| Pages (from-to) | 179-186 |
| Number of pages | 8 |
| Journal | Digestion |
| Volume | 86 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Oct 2012 |
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Keywords
- MALToma
- Radiotherapy
- Stomach
ASJC Scopus subject areas
- Gastroenterology
Cite this
A prospective analysis of efficacy and long-term outcome of radiation therapy for gastric mucosa-associated lymphoid tissue lymphoma. / Okada, Hiroyuki; Takemoto, Mitshuhiro; Kawahara, Yoshiro; Nasu, Junichiro; Takenaka, Ryuta; Kawano, Seiji; Inoue, Masafumi; Ichimura, Koichi; Tanaka, Takehiro; Shinagawa, Katsushi; Yoshino, Tadashi; Yamamoto, Kazuhide.
In: Digestion, Vol. 86, No. 3, 10.2012, p. 179-186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A prospective analysis of efficacy and long-term outcome of radiation therapy for gastric mucosa-associated lymphoid tissue lymphoma
AU - Okada, Hiroyuki
AU - Takemoto, Mitshuhiro
AU - Kawahara, Yoshiro
AU - Nasu, Junichiro
AU - Takenaka, Ryuta
AU - Kawano, Seiji
AU - Inoue, Masafumi
AU - Ichimura, Koichi
AU - Tanaka, Takehiro
AU - Shinagawa, Katsushi
AU - Yoshino, Tadashi
AU - Yamamoto, Kazuhide
PY - 2012/10
Y1 - 2012/10
N2 - Background/Aims: Few studies exist on the efficacy and long-term outcome of radiation therapy (RT) for gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Methods: Twenty-two patients with stage I or stage II1 disease were prospectively evaluated, including 14 patients without Helicobacter pylori(H. pylori) infection and 8 patients with persistent lymphoma after H. pylori eradication. RT dose was 30 Gy in daily fractions of 1.5 Gy. All patients underwent endoscopic and histological follow-up regularly. Results: The study included 22 patients with a mean age of 63 years. The t(11;18)(q21;q21) translocation occurred in 8 of the 22 cases. All patients showed complete remission without any serious toxicity. At a median follow-up evaluation 74 months (range 27-159) after completion of RT, the overall and relapse-free survival rates after 5 years were 91 and 84%, respectively. Although no patient showed local recurrence of lymphoma, distant recurrence was detected in 3 patients, all of whom were H. pylori negative; MALT lymphoma relapsed in two patients with the t(11;18)(q21;q21) translocation, and diffuse large-cell lymphoma developed in one patient without the translocation. Conclusion: RT provides excellent local control of the gastric MALT lymphoma. However, continuous follow-up is mandatory as relapse may occur in other sites.
AB - Background/Aims: Few studies exist on the efficacy and long-term outcome of radiation therapy (RT) for gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Methods: Twenty-two patients with stage I or stage II1 disease were prospectively evaluated, including 14 patients without Helicobacter pylori(H. pylori) infection and 8 patients with persistent lymphoma after H. pylori eradication. RT dose was 30 Gy in daily fractions of 1.5 Gy. All patients underwent endoscopic and histological follow-up regularly. Results: The study included 22 patients with a mean age of 63 years. The t(11;18)(q21;q21) translocation occurred in 8 of the 22 cases. All patients showed complete remission without any serious toxicity. At a median follow-up evaluation 74 months (range 27-159) after completion of RT, the overall and relapse-free survival rates after 5 years were 91 and 84%, respectively. Although no patient showed local recurrence of lymphoma, distant recurrence was detected in 3 patients, all of whom were H. pylori negative; MALT lymphoma relapsed in two patients with the t(11;18)(q21;q21) translocation, and diffuse large-cell lymphoma developed in one patient without the translocation. Conclusion: RT provides excellent local control of the gastric MALT lymphoma. However, continuous follow-up is mandatory as relapse may occur in other sites.
KW - MALToma
KW - Radiotherapy
KW - Stomach
UR - http://www.scopus.com/inward/record.url?scp=84865048429&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865048429&partnerID=8YFLogxK
U2 - 10.1159/000339497
DO - 10.1159/000339497
M3 - Article
VL - 86
SP - 179
EP - 186
JO - Digestion
JF - Digestion
SN - 0012-2823
IS - 3
ER -