A prospective analysis of efficacy and long-term outcome of radiation therapy for gastric mucosa-associated lymphoid tissue lymphoma

Hiroyuki Okada, Mitshuhiro Takemoto, Yoshiro Kawahara, Junichiro Nasu, Ryuta Takenaka, Seiji Kawano, Masafumi Inoue, Koichi Ichimura, Takehiro Tanaka, Katsushi Shinagawa, Tadashi Yoshino, Kazuhide Yamamoto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background/Aims: Few studies exist on the efficacy and long-term outcome of radiation therapy (RT) for gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Methods: Twenty-two patients with stage I or stage II1 disease were prospectively evaluated, including 14 patients without Helicobacter pylori(H. pylori) infection and 8 patients with persistent lymphoma after H. pylori eradication. RT dose was 30 Gy in daily fractions of 1.5 Gy. All patients underwent endoscopic and histological follow-up regularly. Results: The study included 22 patients with a mean age of 63 years. The t(11;18)(q21;q21) translocation occurred in 8 of the 22 cases. All patients showed complete remission without any serious toxicity. At a median follow-up evaluation 74 months (range 27-159) after completion of RT, the overall and relapse-free survival rates after 5 years were 91 and 84%, respectively. Although no patient showed local recurrence of lymphoma, distant recurrence was detected in 3 patients, all of whom were H. pylori negative; MALT lymphoma relapsed in two patients with the t(11;18)(q21;q21) translocation, and diffuse large-cell lymphoma developed in one patient without the translocation. Conclusion: RT provides excellent local control of the gastric MALT lymphoma. However, continuous follow-up is mandatory as relapse may occur in other sites.

Original languageEnglish
Pages (from-to)179-186
Number of pages8
JournalDigestion
Volume86
Issue number3
DOIs
Publication statusPublished - Oct 2012

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Marginal Zone B-Cell Lymphoma
Gastric Mucosa
Radiotherapy
Helicobacter pylori
Recurrence
Lymphoma
Lymphoma, Large B-Cell, Diffuse
Helicobacter Infections
Survival Rate

Keywords

  • MALToma
  • Radiotherapy
  • Stomach

ASJC Scopus subject areas

  • Gastroenterology

Cite this

A prospective analysis of efficacy and long-term outcome of radiation therapy for gastric mucosa-associated lymphoid tissue lymphoma. / Okada, Hiroyuki; Takemoto, Mitshuhiro; Kawahara, Yoshiro; Nasu, Junichiro; Takenaka, Ryuta; Kawano, Seiji; Inoue, Masafumi; Ichimura, Koichi; Tanaka, Takehiro; Shinagawa, Katsushi; Yoshino, Tadashi; Yamamoto, Kazuhide.

In: Digestion, Vol. 86, No. 3, 10.2012, p. 179-186.

Research output: Contribution to journalArticle

Okada, Hiroyuki ; Takemoto, Mitshuhiro ; Kawahara, Yoshiro ; Nasu, Junichiro ; Takenaka, Ryuta ; Kawano, Seiji ; Inoue, Masafumi ; Ichimura, Koichi ; Tanaka, Takehiro ; Shinagawa, Katsushi ; Yoshino, Tadashi ; Yamamoto, Kazuhide. / A prospective analysis of efficacy and long-term outcome of radiation therapy for gastric mucosa-associated lymphoid tissue lymphoma. In: Digestion. 2012 ; Vol. 86, No. 3. pp. 179-186.
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