A promising new anti-cancer strategy: Iron chelators targeting cscs

Yuehua Chen, Toshiaki Ohara, Boyi Xing, Jiping Qi, Kazuhiro Noma, Akihiro Matsukawa

Research output: Contribution to journalArticle

Abstract

Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalActa medica Okayama
Volume74
Issue number1
Publication statusPublished - Jan 1 2020

Keywords

  • Cancer stem cell
  • Chelation
  • Chemotherapy
  • Iron
  • Stemness

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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