A preclinical in vivo investigation of high-intensity focused ultrasound combined with radiotherapy

Chao Xing Liu, Xian Shu Gao, Liu Lin Xiong, Hui Yu Ge, Xin Yong He, Ting Li, Hong Juan Zhang, Hong Zhong Bai, Qiang Lin, Ming Zhang, Jing Zhao, Wei Xiong, Yu Bai, Jun-Ichi Asaumi

Research output: Contribution to journalArticle

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Abstract

This study aims to perform an in vivo investigation evaluating the injury to the pancreas and adjacent tissue of swine resulting with high-intensity focused ultrasound (HIFU) combined with radiotherapy (RT). The protocol was approved by the animal ethics committee at the Peking University First Hospital. A total of 12 domestic swine were divided into four groups: control, HIFU only, RT only and HIFU + RT. The injury to the pancreas, adjacent tissue and tissue within the acoustic path of the HIFU beam was assessed based on gross and histologic findings. For the targeted region of the pancreas, the score of the combined group was higher than that of the HIFU group and there was significant difference. For the acoustic path tissue, there was no significant difference except between the control group and the other groups. HIFU combined with RT increased the injury to the targeted pancreas, without increased injury to tissue outside of the targeted region.

Original languageEnglish
Pages (from-to)69-77
Number of pages9
JournalUltrasound in Medicine and Biology
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 2011

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pancreas
radiation therapy
Radiotherapy
Pancreas
Wounds and Injuries
swine
Acoustics
Swine
Animal Care Committees
Control Groups
ethics
acoustics
animals

Keywords

  • High-intensity focused ultrasound (HIFU)
  • Injury
  • Pancreas
  • Radiotherapy (RT)
  • Swine

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

A preclinical in vivo investigation of high-intensity focused ultrasound combined with radiotherapy. / Liu, Chao Xing; Gao, Xian Shu; Xiong, Liu Lin; Ge, Hui Yu; He, Xin Yong; Li, Ting; Zhang, Hong Juan; Bai, Hong Zhong; Lin, Qiang; Zhang, Ming; Zhao, Jing; Xiong, Wei; Bai, Yu; Asaumi, Jun-Ichi.

In: Ultrasound in Medicine and Biology, Vol. 37, No. 1, 01.2011, p. 69-77.

Research output: Contribution to journalArticle

Liu, CX, Gao, XS, Xiong, LL, Ge, HY, He, XY, Li, T, Zhang, HJ, Bai, HZ, Lin, Q, Zhang, M, Zhao, J, Xiong, W, Bai, Y & Asaumi, J-I 2011, 'A preclinical in vivo investigation of high-intensity focused ultrasound combined with radiotherapy', Ultrasound in Medicine and Biology, vol. 37, no. 1, pp. 69-77. https://doi.org/10.1016/j.ultrasmedbio.2010.10.001
Liu, Chao Xing ; Gao, Xian Shu ; Xiong, Liu Lin ; Ge, Hui Yu ; He, Xin Yong ; Li, Ting ; Zhang, Hong Juan ; Bai, Hong Zhong ; Lin, Qiang ; Zhang, Ming ; Zhao, Jing ; Xiong, Wei ; Bai, Yu ; Asaumi, Jun-Ichi. / A preclinical in vivo investigation of high-intensity focused ultrasound combined with radiotherapy. In: Ultrasound in Medicine and Biology. 2011 ; Vol. 37, No. 1. pp. 69-77.
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