A Potential New Risk Factor for Stroke

Streptococcus Mutans With Collagen-Binding Protein

Chikanori Inenaga, Kazuya Hokamura, Kazuhiko Nakano, Ryota Nomura, Shuhei Naka, Toshihiko Ohashi, Takashi Ooshima, Nagato Kuriyama, Toshimitsu Hamasaki, Koichiro Wada, Kazuo Umemura, Tokutaro Tanaka

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Among human oral bacteria, particular kinds of Streptococcus mutans (SM) known as dental caries pathogens contain a collagen-binding protein, Cnm, and show platelet aggregation inhibition and matrix metalloproteinase-9 activation. We have previously reported that these strains may be a risk factor for intracerebral hemorrhage. As a major sample-providing hospital, we report the clinical details, including intracranial aneurysms and ischemic stroke. Methods: After the study received approval from the Ethical Committee, 429 samples of whole saliva were obtained from patients who were admitted to or visited our hospital between February 16, 2010, and February 28, 2011. The study cohort comprised 48 patients with cardioembolic stroke (CES), 151 with non-CES infarct, 54 with intracerebral hemorrhage (ICH), 43 with ruptured intracranial aneurysm (RIA), and 97 with unruptured intracranial aneurysm (UIA). Cultured SM was identified as Cnm-positive when the corresponding gene was positive. The results were compared with those from 79 healthy volunteers. Relationships between Cnm-positive SM and known risk factors, including hypertension, diabetes, hyperlipidemia, smoking, and alcohol consumption, were analyzed. Results: A statistically significant high Cnm-positive rate was observed in patients with CES, non-CES infarct, ICH, and RIA (P = 0.002, 0.039, 0.013, and 0.009, respectively). There were no relationships between Cnm-positive SM and known risk factors. Conclusions: Specific types of oral SM can be a risk factor for cardioembolic infarct, intracerebral hemorrhage, and intracranial aneurysm rupture. Further study is needed.

Original languageEnglish
Pages (from-to)e77-e81
JournalWorld Neurosurgery
Volume113
DOIs
Publication statusPublished - May 1 2018
Externally publishedYes

Fingerprint

Streptococcus mutans
Intracranial Aneurysm
Cerebral Hemorrhage
Carrier Proteins
Collagen
Stroke
Ruptured Aneurysm
Matrix Metalloproteinase 9
Dental Caries
Hyperlipidemias
Platelet Aggregation
Saliva
Alcohol Drinking
Rupture
Healthy Volunteers
Cohort Studies
Smoking
Hypertension
Bacteria
Genes

Keywords

  • Bacterial infection
  • Cerebrovascular disease/stroke
  • Risk factors in epidemiology

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

A Potential New Risk Factor for Stroke : Streptococcus Mutans With Collagen-Binding Protein. / Inenaga, Chikanori; Hokamura, Kazuya; Nakano, Kazuhiko; Nomura, Ryota; Naka, Shuhei; Ohashi, Toshihiko; Ooshima, Takashi; Kuriyama, Nagato; Hamasaki, Toshimitsu; Wada, Koichiro; Umemura, Kazuo; Tanaka, Tokutaro.

In: World Neurosurgery, Vol. 113, 01.05.2018, p. e77-e81.

Research output: Contribution to journalArticle

Inenaga, C, Hokamura, K, Nakano, K, Nomura, R, Naka, S, Ohashi, T, Ooshima, T, Kuriyama, N, Hamasaki, T, Wada, K, Umemura, K & Tanaka, T 2018, 'A Potential New Risk Factor for Stroke: Streptococcus Mutans With Collagen-Binding Protein', World Neurosurgery, vol. 113, pp. e77-e81. https://doi.org/10.1016/j.wneu.2018.01.158
Inenaga, Chikanori ; Hokamura, Kazuya ; Nakano, Kazuhiko ; Nomura, Ryota ; Naka, Shuhei ; Ohashi, Toshihiko ; Ooshima, Takashi ; Kuriyama, Nagato ; Hamasaki, Toshimitsu ; Wada, Koichiro ; Umemura, Kazuo ; Tanaka, Tokutaro. / A Potential New Risk Factor for Stroke : Streptococcus Mutans With Collagen-Binding Protein. In: World Neurosurgery. 2018 ; Vol. 113. pp. e77-e81.
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abstract = "Background: Among human oral bacteria, particular kinds of Streptococcus mutans (SM) known as dental caries pathogens contain a collagen-binding protein, Cnm, and show platelet aggregation inhibition and matrix metalloproteinase-9 activation. We have previously reported that these strains may be a risk factor for intracerebral hemorrhage. As a major sample-providing hospital, we report the clinical details, including intracranial aneurysms and ischemic stroke. Methods: After the study received approval from the Ethical Committee, 429 samples of whole saliva were obtained from patients who were admitted to or visited our hospital between February 16, 2010, and February 28, 2011. The study cohort comprised 48 patients with cardioembolic stroke (CES), 151 with non-CES infarct, 54 with intracerebral hemorrhage (ICH), 43 with ruptured intracranial aneurysm (RIA), and 97 with unruptured intracranial aneurysm (UIA). Cultured SM was identified as Cnm-positive when the corresponding gene was positive. The results were compared with those from 79 healthy volunteers. Relationships between Cnm-positive SM and known risk factors, including hypertension, diabetes, hyperlipidemia, smoking, and alcohol consumption, were analyzed. Results: A statistically significant high Cnm-positive rate was observed in patients with CES, non-CES infarct, ICH, and RIA (P = 0.002, 0.039, 0.013, and 0.009, respectively). There were no relationships between Cnm-positive SM and known risk factors. Conclusions: Specific types of oral SM can be a risk factor for cardioembolic infarct, intracerebral hemorrhage, and intracranial aneurysm rupture. Further study is needed.",
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T1 - A Potential New Risk Factor for Stroke

T2 - Streptococcus Mutans With Collagen-Binding Protein

AU - Inenaga, Chikanori

AU - Hokamura, Kazuya

AU - Nakano, Kazuhiko

AU - Nomura, Ryota

AU - Naka, Shuhei

AU - Ohashi, Toshihiko

AU - Ooshima, Takashi

AU - Kuriyama, Nagato

AU - Hamasaki, Toshimitsu

AU - Wada, Koichiro

AU - Umemura, Kazuo

AU - Tanaka, Tokutaro

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: Among human oral bacteria, particular kinds of Streptococcus mutans (SM) known as dental caries pathogens contain a collagen-binding protein, Cnm, and show platelet aggregation inhibition and matrix metalloproteinase-9 activation. We have previously reported that these strains may be a risk factor for intracerebral hemorrhage. As a major sample-providing hospital, we report the clinical details, including intracranial aneurysms and ischemic stroke. Methods: After the study received approval from the Ethical Committee, 429 samples of whole saliva were obtained from patients who were admitted to or visited our hospital between February 16, 2010, and February 28, 2011. The study cohort comprised 48 patients with cardioembolic stroke (CES), 151 with non-CES infarct, 54 with intracerebral hemorrhage (ICH), 43 with ruptured intracranial aneurysm (RIA), and 97 with unruptured intracranial aneurysm (UIA). Cultured SM was identified as Cnm-positive when the corresponding gene was positive. The results were compared with those from 79 healthy volunteers. Relationships between Cnm-positive SM and known risk factors, including hypertension, diabetes, hyperlipidemia, smoking, and alcohol consumption, were analyzed. Results: A statistically significant high Cnm-positive rate was observed in patients with CES, non-CES infarct, ICH, and RIA (P = 0.002, 0.039, 0.013, and 0.009, respectively). There were no relationships between Cnm-positive SM and known risk factors. Conclusions: Specific types of oral SM can be a risk factor for cardioembolic infarct, intracerebral hemorrhage, and intracranial aneurysm rupture. Further study is needed.

AB - Background: Among human oral bacteria, particular kinds of Streptococcus mutans (SM) known as dental caries pathogens contain a collagen-binding protein, Cnm, and show platelet aggregation inhibition and matrix metalloproteinase-9 activation. We have previously reported that these strains may be a risk factor for intracerebral hemorrhage. As a major sample-providing hospital, we report the clinical details, including intracranial aneurysms and ischemic stroke. Methods: After the study received approval from the Ethical Committee, 429 samples of whole saliva were obtained from patients who were admitted to or visited our hospital between February 16, 2010, and February 28, 2011. The study cohort comprised 48 patients with cardioembolic stroke (CES), 151 with non-CES infarct, 54 with intracerebral hemorrhage (ICH), 43 with ruptured intracranial aneurysm (RIA), and 97 with unruptured intracranial aneurysm (UIA). Cultured SM was identified as Cnm-positive when the corresponding gene was positive. The results were compared with those from 79 healthy volunteers. Relationships between Cnm-positive SM and known risk factors, including hypertension, diabetes, hyperlipidemia, smoking, and alcohol consumption, were analyzed. Results: A statistically significant high Cnm-positive rate was observed in patients with CES, non-CES infarct, ICH, and RIA (P = 0.002, 0.039, 0.013, and 0.009, respectively). There were no relationships between Cnm-positive SM and known risk factors. Conclusions: Specific types of oral SM can be a risk factor for cardioembolic infarct, intracerebral hemorrhage, and intracranial aneurysm rupture. Further study is needed.

KW - Bacterial infection

KW - Cerebrovascular disease/stroke

KW - Risk factors in epidemiology

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JF - World Neurosurgery

SN - 1878-8750

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