A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer

Mikdat Bozer, Fatma Aşik, Muradiye Acar, Hacer Haltaş, Sibel Yenidünya, Metin Canbal, Vehap Topçu, Muhammet Ramazan Yiǧitoǧlu, Mehmet Gündüz, Esra Gündüz, Satoshi Hirohata, Kadir Demircan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: We investigated the effect of the number of cytosine-adenine (CA) repeats in the ADAMTS9 promoter region on breast cancer lymphatic metastasis. Materials and methods: Thirty-one postoperative breast cancer patients were selected and examined retrospectively. The patients were classified into 2 groups: metastatic or nonmetastatic. Thirty healthy women were selected as the control group, and their peripheral blood was obtained. Following DNA isolation from the cancer tissue specimens and peripheral blood, the promoter region of the ADAMTS9 gene was directly sequenced and the number of CA repeats was determined. Results: The number of CA repeats ranged between 19 and 21 in the control and metastatic groups. However, in the nonmetastatic group, the number of CA repeats ranged between 17 and 18. This difference in the median number of CA repeats between the control group and the nonmetastatic group was statistically significant. Conclusion: A potential relationship may exist between lymphatic metastasis in breast cancer and the number of CA repeats in the promoter region of the ADAMTS9 gene. Our study indicates a potential association between the number of CA microsatellite repeats in the promoter region of the ADAMTS9 gene and breast cancer lymphatic metastasis.

Original languageEnglish
Pages (from-to)671-677
Number of pages7
JournalTurkish Journal of Medical Sciences
Volume43
Issue number5
DOIs
Publication statusPublished - 2013

Fingerprint

Lymphatic Metastasis
Cytosine
Adenine
Genetic Promoter Regions
Breast Neoplasms
Genes
Control Groups
Microsatellite Repeats
DNA

Keywords

  • ADAMTS9 gene
  • Breast cancer
  • Dinucleotide repeats
  • Lymphatic metastasis
  • Promoter region

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer. / Bozer, Mikdat; Aşik, Fatma; Acar, Muradiye; Haltaş, Hacer; Yenidünya, Sibel; Canbal, Metin; Topçu, Vehap; Yiǧitoǧlu, Muhammet Ramazan; Gündüz, Mehmet; Gündüz, Esra; Hirohata, Satoshi; Demircan, Kadir.

In: Turkish Journal of Medical Sciences, Vol. 43, No. 5, 2013, p. 671-677.

Research output: Contribution to journalArticle

Bozer, M, Aşik, F, Acar, M, Haltaş, H, Yenidünya, S, Canbal, M, Topçu, V, Yiǧitoǧlu, MR, Gündüz, M, Gündüz, E, Hirohata, S & Demircan, K 2013, 'A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer', Turkish Journal of Medical Sciences, vol. 43, no. 5, pp. 671-677. https://doi.org/10.3906/sag-1210-84
Bozer, Mikdat ; Aşik, Fatma ; Acar, Muradiye ; Haltaş, Hacer ; Yenidünya, Sibel ; Canbal, Metin ; Topçu, Vehap ; Yiǧitoǧlu, Muhammet Ramazan ; Gündüz, Mehmet ; Gündüz, Esra ; Hirohata, Satoshi ; Demircan, Kadir. / A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer. In: Turkish Journal of Medical Sciences. 2013 ; Vol. 43, No. 5. pp. 671-677.
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AU - Bozer, Mikdat

AU - Aşik, Fatma

AU - Acar, Muradiye

AU - Haltaş, Hacer

AU - Yenidünya, Sibel

AU - Canbal, Metin

AU - Topçu, Vehap

AU - Yiǧitoǧlu, Muhammet Ramazan

AU - Gündüz, Mehmet

AU - Gündüz, Esra

AU - Hirohata, Satoshi

AU - Demircan, Kadir

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N2 - Aim: We investigated the effect of the number of cytosine-adenine (CA) repeats in the ADAMTS9 promoter region on breast cancer lymphatic metastasis. Materials and methods: Thirty-one postoperative breast cancer patients were selected and examined retrospectively. The patients were classified into 2 groups: metastatic or nonmetastatic. Thirty healthy women were selected as the control group, and their peripheral blood was obtained. Following DNA isolation from the cancer tissue specimens and peripheral blood, the promoter region of the ADAMTS9 gene was directly sequenced and the number of CA repeats was determined. Results: The number of CA repeats ranged between 19 and 21 in the control and metastatic groups. However, in the nonmetastatic group, the number of CA repeats ranged between 17 and 18. This difference in the median number of CA repeats between the control group and the nonmetastatic group was statistically significant. Conclusion: A potential relationship may exist between lymphatic metastasis in breast cancer and the number of CA repeats in the promoter region of the ADAMTS9 gene. Our study indicates a potential association between the number of CA microsatellite repeats in the promoter region of the ADAMTS9 gene and breast cancer lymphatic metastasis.

AB - Aim: We investigated the effect of the number of cytosine-adenine (CA) repeats in the ADAMTS9 promoter region on breast cancer lymphatic metastasis. Materials and methods: Thirty-one postoperative breast cancer patients were selected and examined retrospectively. The patients were classified into 2 groups: metastatic or nonmetastatic. Thirty healthy women were selected as the control group, and their peripheral blood was obtained. Following DNA isolation from the cancer tissue specimens and peripheral blood, the promoter region of the ADAMTS9 gene was directly sequenced and the number of CA repeats was determined. Results: The number of CA repeats ranged between 19 and 21 in the control and metastatic groups. However, in the nonmetastatic group, the number of CA repeats ranged between 17 and 18. This difference in the median number of CA repeats between the control group and the nonmetastatic group was statistically significant. Conclusion: A potential relationship may exist between lymphatic metastasis in breast cancer and the number of CA repeats in the promoter region of the ADAMTS9 gene. Our study indicates a potential association between the number of CA microsatellite repeats in the promoter region of the ADAMTS9 gene and breast cancer lymphatic metastasis.

KW - ADAMTS9 gene

KW - Breast cancer

KW - Dinucleotide repeats

KW - Lymphatic metastasis

KW - Promoter region

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