A possible role for calmodulin in Ca2+-induced swelling of mitochondria

O. Hatase, T. Itano, H. Matsui, A. Doi, S. Etoh, H. Nishio, S. Nakahara

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Abstract

Ca2+-induced mitochondrial swelling was inhibited by a low concentration of calmodulin antagonists. Two affinities of Ca2+ to mitochondrial swelling were observed: high (2-5 μM) and low (more than 100 μM) systems. The high-affinity change was inhibited by micromolar level of trifluoperazine and W-7, but not by W-5. The possible mechanism of this inhibition and the role of CaM in mitochondria are discussed.

Original languageEnglish
Pages (from-to)793-799
Number of pages7
JournalBiochemistry International
Volume15
Issue number4
Publication statusPublished - Dec 1 1987

ASJC Scopus subject areas

  • Biochemistry

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    Hatase, O., Itano, T., Matsui, H., Doi, A., Etoh, S., Nishio, H., & Nakahara, S. (1987). A possible role for calmodulin in Ca2+-induced swelling of mitochondria. Biochemistry International, 15(4), 793-799.