Abstract
Ca2+-induced mitochondrial swelling was inhibited by a low concentration of calmodulin antagonists. Two affinities of Ca2+ to mitochondrial swelling were observed: high (2-5 μM) and low (more than 100 μM) systems. The high-affinity change was inhibited by micromolar level of trifluoperazine and W-7, but not by W-5. The possible mechanism of this inhibition and the role of CaM in mitochondria are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 793-799 |
| Number of pages | 7 |
| Journal | Biochemistry International |
| Volume | 15 |
| Issue number | 4 |
| Publication status | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
Cite this
A possible role for calmodulin in Ca2+-induced swelling of mitochondria. / Hatase, O.; Itano, T.; Matsui, Hideki; Doi, A.; Etoh, S.; Nishio, H.; Nakahara, S.
In: Biochemistry International, Vol. 15, No. 4, 1987, p. 793-799.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A possible role for calmodulin in Ca2+-induced swelling of mitochondria
AU - Hatase, O.
AU - Itano, T.
AU - Matsui, Hideki
AU - Doi, A.
AU - Etoh, S.
AU - Nishio, H.
AU - Nakahara, S.
PY - 1987
Y1 - 1987
N2 - Ca2+-induced mitochondrial swelling was inhibited by a low concentration of calmodulin antagonists. Two affinities of Ca2+ to mitochondrial swelling were observed: high (2-5 μM) and low (more than 100 μM) systems. The high-affinity change was inhibited by micromolar level of trifluoperazine and W-7, but not by W-5. The possible mechanism of this inhibition and the role of CaM in mitochondria are discussed.
AB - Ca2+-induced mitochondrial swelling was inhibited by a low concentration of calmodulin antagonists. Two affinities of Ca2+ to mitochondrial swelling were observed: high (2-5 μM) and low (more than 100 μM) systems. The high-affinity change was inhibited by micromolar level of trifluoperazine and W-7, but not by W-5. The possible mechanism of this inhibition and the role of CaM in mitochondria are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0023626160&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023626160&partnerID=8YFLogxK
M3 - Article
C2 - 3435542
AN - SCOPUS:0023626160
VL - 15
SP - 793
EP - 799
JO - IUBMB Life
JF - IUBMB Life
SN - 1521-6543
IS - 4
ER -