A possible role for calmodulin in Ca2+-induced swelling of mitochondria

O. Hatase, T. Itano, Hideki Matsui, A. Doi, S. Etoh, H. Nishio, S. Nakahara

Research output: Contribution to journalArticle

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Abstract

Ca2+-induced mitochondrial swelling was inhibited by a low concentration of calmodulin antagonists. Two affinities of Ca2+ to mitochondrial swelling were observed: high (2-5 μM) and low (more than 100 μM) systems. The high-affinity change was inhibited by micromolar level of trifluoperazine and W-7, but not by W-5. The possible mechanism of this inhibition and the role of CaM in mitochondria are discussed.

Original languageEnglish
Pages (from-to)793-799
Number of pages7
JournalBiochemistry International
Volume15
Issue number4
Publication statusPublished - 1987
Externally publishedYes

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Mitochondrial Swelling
Mitochondria
Calmodulin
Swelling
Trifluoperazine
N-(6-aminohexyl)-1-naphthalenesulfonamide
W 7

ASJC Scopus subject areas

  • Biochemistry

Cite this

Hatase, O., Itano, T., Matsui, H., Doi, A., Etoh, S., Nishio, H., & Nakahara, S. (1987). A possible role for calmodulin in Ca2+-induced swelling of mitochondria. Biochemistry International, 15(4), 793-799.

A possible role for calmodulin in Ca2+-induced swelling of mitochondria. / Hatase, O.; Itano, T.; Matsui, Hideki; Doi, A.; Etoh, S.; Nishio, H.; Nakahara, S.

In: Biochemistry International, Vol. 15, No. 4, 1987, p. 793-799.

Research output: Contribution to journalArticle

Hatase, O, Itano, T, Matsui, H, Doi, A, Etoh, S, Nishio, H & Nakahara, S 1987, 'A possible role for calmodulin in Ca2+-induced swelling of mitochondria', Biochemistry International, vol. 15, no. 4, pp. 793-799.
Hatase O, Itano T, Matsui H, Doi A, Etoh S, Nishio H et al. A possible role for calmodulin in Ca2+-induced swelling of mitochondria. Biochemistry International. 1987;15(4):793-799.
Hatase, O. ; Itano, T. ; Matsui, Hideki ; Doi, A. ; Etoh, S. ; Nishio, H. ; Nakahara, S. / A possible role for calmodulin in Ca2+-induced swelling of mitochondria. In: Biochemistry International. 1987 ; Vol. 15, No. 4. pp. 793-799.
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