A possible new morphological variant of mantle cell lymphoma with plasma-cell type Castleman disease-like features

Takuro Igawa, Rika Omote, Hiaki Sato, Kouhei Taniguchi, Katsuya Miyatani, Tadashi Yoshino, Yasuharu Sato

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1 Citation (Scopus)

Abstract

Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by overexpression of cyclin D1 resulting from t(11;14)(q13;q32) translocation. Herein, we report 3 cases of MCL with features of plasma cell-type Castleman disease (CD). The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of C-reactive protein, and polyclonal hypergammaglobulinemia. Lymph node biopsy specimens of the 3 cases showed histological features of plasma cell-type CD, including atrophic germinal centers and interfollicular plasmacytosis, with no light chain restriction. However, flow cytometric analysis demonstrated an abnormal B-cell population with CD5 expression, and further analysis using cyclin D1 immunostaining highlighted a neoplastic component that was restricted to the mantle zone. These neoplastic cells were immunohistochemically positive for CD20, CD5, and SOX11, and negative for CD3, CD10, and HHV8. The Ki67 index was low. All patients were finally diagnosed with MCL. This rare type of MCL can be misdiagnosed clinically and histologically as CD. Therefore, it is important to recognize this rare type of MCL, and careful examination is required using both histological and flow cytometric analyses.

Original languageEnglish
JournalPathology Research and Practice
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Giant Lymph Node Hyperplasia
Mantle-Cell Lymphoma
Plasma Cells
Cyclin D1
Hypergammaglobulinemia
Hypoalbuminemia
Germinal Center
B-Cell Lymphoma
Diagnostic Errors
C-Reactive Protein
Anemia
B-Lymphocytes
Lymph Nodes
Biopsy
Light
Serum
Population

Keywords

  • Hyper IL-6 syndrome
  • Mantle cell lymphoma
  • Multicentric castleman disease
  • Plasma-cell type Castleman disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

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title = "A possible new morphological variant of mantle cell lymphoma with plasma-cell type Castleman disease-like features",
abstract = "Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by overexpression of cyclin D1 resulting from t(11;14)(q13;q32) translocation. Herein, we report 3 cases of MCL with features of plasma cell-type Castleman disease (CD). The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of C-reactive protein, and polyclonal hypergammaglobulinemia. Lymph node biopsy specimens of the 3 cases showed histological features of plasma cell-type CD, including atrophic germinal centers and interfollicular plasmacytosis, with no light chain restriction. However, flow cytometric analysis demonstrated an abnormal B-cell population with CD5 expression, and further analysis using cyclin D1 immunostaining highlighted a neoplastic component that was restricted to the mantle zone. These neoplastic cells were immunohistochemically positive for CD20, CD5, and SOX11, and negative for CD3, CD10, and HHV8. The Ki67 index was low. All patients were finally diagnosed with MCL. This rare type of MCL can be misdiagnosed clinically and histologically as CD. Therefore, it is important to recognize this rare type of MCL, and careful examination is required using both histological and flow cytometric analyses.",
keywords = "Hyper IL-6 syndrome, Mantle cell lymphoma, Multicentric castleman disease, Plasma-cell type Castleman disease",
author = "Takuro Igawa and Rika Omote and Hiaki Sato and Kouhei Taniguchi and Katsuya Miyatani and Tadashi Yoshino and Yasuharu Sato",
year = "2017",
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T1 - A possible new morphological variant of mantle cell lymphoma with plasma-cell type Castleman disease-like features

AU - Igawa, Takuro

AU - Omote, Rika

AU - Sato, Hiaki

AU - Taniguchi, Kouhei

AU - Miyatani, Katsuya

AU - Yoshino, Tadashi

AU - Sato, Yasuharu

PY - 2017

Y1 - 2017

N2 - Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by overexpression of cyclin D1 resulting from t(11;14)(q13;q32) translocation. Herein, we report 3 cases of MCL with features of plasma cell-type Castleman disease (CD). The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of C-reactive protein, and polyclonal hypergammaglobulinemia. Lymph node biopsy specimens of the 3 cases showed histological features of plasma cell-type CD, including atrophic germinal centers and interfollicular plasmacytosis, with no light chain restriction. However, flow cytometric analysis demonstrated an abnormal B-cell population with CD5 expression, and further analysis using cyclin D1 immunostaining highlighted a neoplastic component that was restricted to the mantle zone. These neoplastic cells were immunohistochemically positive for CD20, CD5, and SOX11, and negative for CD3, CD10, and HHV8. The Ki67 index was low. All patients were finally diagnosed with MCL. This rare type of MCL can be misdiagnosed clinically and histologically as CD. Therefore, it is important to recognize this rare type of MCL, and careful examination is required using both histological and flow cytometric analyses.

AB - Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by overexpression of cyclin D1 resulting from t(11;14)(q13;q32) translocation. Herein, we report 3 cases of MCL with features of plasma cell-type Castleman disease (CD). The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of C-reactive protein, and polyclonal hypergammaglobulinemia. Lymph node biopsy specimens of the 3 cases showed histological features of plasma cell-type CD, including atrophic germinal centers and interfollicular plasmacytosis, with no light chain restriction. However, flow cytometric analysis demonstrated an abnormal B-cell population with CD5 expression, and further analysis using cyclin D1 immunostaining highlighted a neoplastic component that was restricted to the mantle zone. These neoplastic cells were immunohistochemically positive for CD20, CD5, and SOX11, and negative for CD3, CD10, and HHV8. The Ki67 index was low. All patients were finally diagnosed with MCL. This rare type of MCL can be misdiagnosed clinically and histologically as CD. Therefore, it is important to recognize this rare type of MCL, and careful examination is required using both histological and flow cytometric analyses.

KW - Hyper IL-6 syndrome

KW - Mantle cell lymphoma

KW - Multicentric castleman disease

KW - Plasma-cell type Castleman disease

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