Abstract
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by overexpression of cyclin D1 resulting from t(11;14)(q13;q32) translocation. Herein, we report 3 cases of MCL with features of plasma cell-type Castleman disease (CD). The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of C-reactive protein, and polyclonal hypergammaglobulinemia. Lymph node biopsy specimens of the 3 cases showed histological features of plasma cell-type CD, including atrophic germinal centers and interfollicular plasmacytosis, with no light chain restriction. However, flow cytometric analysis demonstrated an abnormal B-cell population with CD5 expression, and further analysis using cyclin D1 immunostaining highlighted a neoplastic component that was restricted to the mantle zone. These neoplastic cells were immunohistochemically positive for CD20, CD5, and SOX11, and negative for CD3, CD10, and HHV8. The Ki67 index was low. All patients were finally diagnosed with MCL. This rare type of MCL can be misdiagnosed clinically and histologically as CD. Therefore, it is important to recognize this rare type of MCL, and careful examination is required using both histological and flow cytometric analyses.
| Original language | English |
|---|---|
| Journal | Pathology Research and Practice |
| DOIs | |
| Publication status | Accepted/In press - 2017 |
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Keywords
- Hyper IL-6 syndrome
- Mantle cell lymphoma
- Multicentric castleman disease
- Plasma-cell type Castleman disease
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Cell Biology
Cite this
A possible new morphological variant of mantle cell lymphoma with plasma-cell type Castleman disease-like features. / Igawa, Takuro; Omote, Rika; Sato, Hiaki; Taniguchi, Kouhei; Miyatani, Katsuya; Yoshino, Tadashi; Sato, Yasuharu.
In: Pathology Research and Practice, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A possible new morphological variant of mantle cell lymphoma with plasma-cell type Castleman disease-like features
AU - Igawa, Takuro
AU - Omote, Rika
AU - Sato, Hiaki
AU - Taniguchi, Kouhei
AU - Miyatani, Katsuya
AU - Yoshino, Tadashi
AU - Sato, Yasuharu
PY - 2017
Y1 - 2017
N2 - Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by overexpression of cyclin D1 resulting from t(11;14)(q13;q32) translocation. Herein, we report 3 cases of MCL with features of plasma cell-type Castleman disease (CD). The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of C-reactive protein, and polyclonal hypergammaglobulinemia. Lymph node biopsy specimens of the 3 cases showed histological features of plasma cell-type CD, including atrophic germinal centers and interfollicular plasmacytosis, with no light chain restriction. However, flow cytometric analysis demonstrated an abnormal B-cell population with CD5 expression, and further analysis using cyclin D1 immunostaining highlighted a neoplastic component that was restricted to the mantle zone. These neoplastic cells were immunohistochemically positive for CD20, CD5, and SOX11, and negative for CD3, CD10, and HHV8. The Ki67 index was low. All patients were finally diagnosed with MCL. This rare type of MCL can be misdiagnosed clinically and histologically as CD. Therefore, it is important to recognize this rare type of MCL, and careful examination is required using both histological and flow cytometric analyses.
AB - Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by overexpression of cyclin D1 resulting from t(11;14)(q13;q32) translocation. Herein, we report 3 cases of MCL with features of plasma cell-type Castleman disease (CD). The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of C-reactive protein, and polyclonal hypergammaglobulinemia. Lymph node biopsy specimens of the 3 cases showed histological features of plasma cell-type CD, including atrophic germinal centers and interfollicular plasmacytosis, with no light chain restriction. However, flow cytometric analysis demonstrated an abnormal B-cell population with CD5 expression, and further analysis using cyclin D1 immunostaining highlighted a neoplastic component that was restricted to the mantle zone. These neoplastic cells were immunohistochemically positive for CD20, CD5, and SOX11, and negative for CD3, CD10, and HHV8. The Ki67 index was low. All patients were finally diagnosed with MCL. This rare type of MCL can be misdiagnosed clinically and histologically as CD. Therefore, it is important to recognize this rare type of MCL, and careful examination is required using both histological and flow cytometric analyses.
KW - Hyper IL-6 syndrome
KW - Mantle cell lymphoma
KW - Multicentric castleman disease
KW - Plasma-cell type Castleman disease
UR - http://www.scopus.com/inward/record.url?scp=85030152441&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030152441&partnerID=8YFLogxK
U2 - 10.1016/j.prp.2017.09.015
DO - 10.1016/j.prp.2017.09.015
M3 - Article
C2 - 28974340
AN - SCOPUS:85030152441
JO - Pathology Research and Practice
JF - Pathology Research and Practice
SN - 0344-0338
ER -