A possible involvement of melanocortin 3 receptor in the regulation of adrenal gland function in the chicken

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The melanocortin 3 receptor (MC3-R) in the melanocortin receptor family has been identified as a neural receptor subtype mainly expressed in the brain in mammals. We report here the isolation of the chicken gene for MC3-R, CMC3, displaying different tissue distribution from mammalian counterparts. The CMC3 gene was found to be a single copy gene encoding a 325 amino acid protein, sharing 75.3-76.8% identity with mammalian counterparts. When assessed by RT-PCR, the CMC3 mRNA was not detected in the brain but was exclusively expressed in adrenal glands, where Agouti-related protein/Agouti-related transcript (AGRP/ART), a newly identified endogenous antagonist of MC3-R, is expressed in mammals, raising the possibility that the CMC3 plays a role in complicated regulation of the gland function by melanocortins and AGRP/ART in the chicken. Noteworthy, MC1-R gene was found to be a quite unique member of the chicken MC-R family with regard to GC content and codon usage. It may reflect as yet unidentified evolutionary pressure operating specifically on the gene. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)512-518
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Issue number3
Publication statusPublished - Jan 11 1999



  • Chicken
  • Codon usage
  • GC content
  • Genomic sequencing
  • Melanocortin 3 receptor
  • Tissue distribution

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Biophysics

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