A polymorphism detected in a variable number of tandem repeats (VNTR) of the seminal vesicle secretion (SVS) IV gene in inbred rats

Eiji Kobayashi; Hiroshi Ikadai; Tomonori Imamichi; Tetsuo Kunieda

doi:10.1007/BF00569324

A polymorphism detected in a variable number of tandem repeats (VNTR) of the seminal vesicle secretion (SVS) IV gene in inbred rats

Eiji Kobayashi, Hiroshi Ikadai, Tomonori Imamichi, Tetsuo Kunieda

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The second intron of the rat SVS IV gene contains a tandem repeat region of 20-bp sequences. This region was amplified using the polymerase chain reaction to detect variations. Three alleles, characterized by amplified fragments of 750, 490, and 390 bp, respectively, were found in 24 strains examined. This variation segregated in F₁ and backcross progeny in an autosomal codominant manner. We tentatively designated this locus Svs-4. Analysis of linkages between the Svs-4 locus and other loci revealed that it was closely linked to the Svp-1 (<2.9%) and the a (10.0±6.7%) loci, which belong to rat linkage group IV. The Svp-1 and Svs-4 loci, however, were differently distributed among the inbred rat strains.

Original language	English
Pages (from-to)	339-346
Number of pages	8
Journal	Biochemical Genetics
Volume	30
Issue number	7-8
DOIs	https://doi.org/10.1007/BF00569324
Publication status	Published - Aug 1 1992
Externally published	Yes

Keywords

DNA polymorphism
Rattus norvegicus
mammalian genetics
seminal vesicle secretion IV (SVS IV) gene
variable number of tandem repeats (VNTRs)

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Biochemistry
Molecular Biology
Genetics

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title = "A polymorphism detected in a variable number of tandem repeats (VNTR) of the seminal vesicle secretion (SVS) IV gene in inbred rats",

abstract = "The second intron of the rat SVS IV gene contains a tandem repeat region of 20-bp sequences. This region was amplified using the polymerase chain reaction to detect variations. Three alleles, characterized by amplified fragments of 750, 490, and 390 bp, respectively, were found in 24 strains examined. This variation segregated in F1 and backcross progeny in an autosomal codominant manner. We tentatively designated this locus Svs-4. Analysis of linkages between the Svs-4 locus and other loci revealed that it was closely linked to the Svp-1 (<2.9%) and the a (10.0±6.7%) loci, which belong to rat linkage group IV. The Svp-1 and Svs-4 loci, however, were differently distributed among the inbred rat strains.",

keywords = "DNA polymorphism, Rattus norvegicus, mammalian genetics, seminal vesicle secretion IV (SVS IV) gene, variable number of tandem repeats (VNTRs)",

author = "Eiji Kobayashi and Hiroshi Ikadai and Tomonori Imamichi and Tetsuo Kunieda",

year = "1992",

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doi = "10.1007/BF00569324",

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T1 - A polymorphism detected in a variable number of tandem repeats (VNTR) of the seminal vesicle secretion (SVS) IV gene in inbred rats

AU - Kobayashi, Eiji

AU - Ikadai, Hiroshi

AU - Imamichi, Tomonori

AU - Kunieda, Tetsuo

PY - 1992/8/1

Y1 - 1992/8/1

N2 - The second intron of the rat SVS IV gene contains a tandem repeat region of 20-bp sequences. This region was amplified using the polymerase chain reaction to detect variations. Three alleles, characterized by amplified fragments of 750, 490, and 390 bp, respectively, were found in 24 strains examined. This variation segregated in F1 and backcross progeny in an autosomal codominant manner. We tentatively designated this locus Svs-4. Analysis of linkages between the Svs-4 locus and other loci revealed that it was closely linked to the Svp-1 (<2.9%) and the a (10.0±6.7%) loci, which belong to rat linkage group IV. The Svp-1 and Svs-4 loci, however, were differently distributed among the inbred rat strains.

AB - The second intron of the rat SVS IV gene contains a tandem repeat region of 20-bp sequences. This region was amplified using the polymerase chain reaction to detect variations. Three alleles, characterized by amplified fragments of 750, 490, and 390 bp, respectively, were found in 24 strains examined. This variation segregated in F1 and backcross progeny in an autosomal codominant manner. We tentatively designated this locus Svs-4. Analysis of linkages between the Svs-4 locus and other loci revealed that it was closely linked to the Svp-1 (<2.9%) and the a (10.0±6.7%) loci, which belong to rat linkage group IV. The Svp-1 and Svs-4 loci, however, were differently distributed among the inbred rat strains.

KW - DNA polymorphism

KW - Rattus norvegicus

KW - mammalian genetics

KW - seminal vesicle secretion IV (SVS IV) gene

KW - variable number of tandem repeats (VNTRs)

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A polymorphism detected in a variable number of tandem repeats (VNTR) of the seminal vesicle secretion (SVS) IV gene in inbred rats

Abstract

Keywords

ASJC Scopus subject areas

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