A polymorphism detected in a variable number of tandem repeats (VNTR) of the seminal vesicle secretion (SVS) IV gene in inbred rats

Eiji Kobayashi, Hiroshi Ikadai, Tomonori Imamichi, Tetsuo Kunieda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The second intron of the rat SVS IV gene contains a tandem repeat region of 20-bp sequences. This region was amplified using the polymerase chain reaction to detect variations. Three alleles, characterized by amplified fragments of 750, 490, and 390 bp, respectively, were found in 24 strains examined. This variation segregated in F1 and backcross progeny in an autosomal codominant manner. We tentatively designated this locus Svs-4. Analysis of linkages between the Svs-4 locus and other loci revealed that it was closely linked to the Svp-1 (<2.9%) and the a (10.0±6.7%) loci, which belong to rat linkage group IV. The Svp-1 and Svs-4 loci, however, were differently distributed among the inbred rat strains.

Original languageEnglish
Pages (from-to)339-346
Number of pages8
JournalBiochemical Genetics
Volume30
Issue number7-8
DOIs
Publication statusPublished - Aug 1 1992
Externally publishedYes

Keywords

  • DNA polymorphism
  • Rattus norvegicus
  • mammalian genetics
  • seminal vesicle secretion IV (SVS IV) gene
  • variable number of tandem repeats (VNTRs)

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Molecular Biology
  • Genetics

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