A planar-type leakage current and impedance microsensor for detection of interaction between electrolyte-entrapping liposome and protein

Y. Ohara, P. Lorchirachoonkul, K. Yamashita, M. Noda, O. A. Alberto, Toshinori Shimanouchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a new leakage current microsensor by using simpler planar processes than Si-surface-bulk micromachining processes used in the previous microwell structure. This sensor fabrication and structure can easily make a target solution volume smaller than μL with excellent immobilization of the droplet and intact biomolecules as sensing elements, as a result, reduce effectively the background noise current in the microsensor and improve reproducibility of the results. The leakage current due to the biochemical interaction was successfully evaluated. Cole-Cole plots from the impedance analysis also show quantitative difference between with and without the interaction, depending on the charge-transfer impedance.

Original languageEnglish
Title of host publicationIMFEDK 2012 - 2012 International Meeting for Future of Electron Devices, Kansai
Pages146-147
Number of pages2
DOIs
Publication statusPublished - 2012
Externally publishedYes
Event10th International Meeting for Future of Electron Devices, Kansai, IMFEDK 2012 - Osaka, Japan
Duration: May 9 2012May 11 2012

Other

Other10th International Meeting for Future of Electron Devices, Kansai, IMFEDK 2012
CountryJapan
CityOsaka
Period5/9/125/11/12

Fingerprint

Microsensors
Liposomes
Leakage currents
Electrolytes
Proteins
Micromachining
Biomolecules
Charge transfer
Fabrication
Sensors

Keywords

  • electrochemical
  • impedance
  • leakage current
  • liposome
  • microsensor
  • protein

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Ohara, Y., Lorchirachoonkul, P., Yamashita, K., Noda, M., Alberto, O. A., & Shimanouchi, T. (2012). A planar-type leakage current and impedance microsensor for detection of interaction between electrolyte-entrapping liposome and protein. In IMFEDK 2012 - 2012 International Meeting for Future of Electron Devices, Kansai (pp. 146-147). [6218624] https://doi.org/10.1109/IMFEDK.2012.6218624

A planar-type leakage current and impedance microsensor for detection of interaction between electrolyte-entrapping liposome and protein. / Ohara, Y.; Lorchirachoonkul, P.; Yamashita, K.; Noda, M.; Alberto, O. A.; Shimanouchi, Toshinori.

IMFEDK 2012 - 2012 International Meeting for Future of Electron Devices, Kansai. 2012. p. 146-147 6218624.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ohara, Y, Lorchirachoonkul, P, Yamashita, K, Noda, M, Alberto, OA & Shimanouchi, T 2012, A planar-type leakage current and impedance microsensor for detection of interaction between electrolyte-entrapping liposome and protein. in IMFEDK 2012 - 2012 International Meeting for Future of Electron Devices, Kansai., 6218624, pp. 146-147, 10th International Meeting for Future of Electron Devices, Kansai, IMFEDK 2012, Osaka, Japan, 5/9/12. https://doi.org/10.1109/IMFEDK.2012.6218624
Ohara Y, Lorchirachoonkul P, Yamashita K, Noda M, Alberto OA, Shimanouchi T. A planar-type leakage current and impedance microsensor for detection of interaction between electrolyte-entrapping liposome and protein. In IMFEDK 2012 - 2012 International Meeting for Future of Electron Devices, Kansai. 2012. p. 146-147. 6218624 https://doi.org/10.1109/IMFEDK.2012.6218624
Ohara, Y. ; Lorchirachoonkul, P. ; Yamashita, K. ; Noda, M. ; Alberto, O. A. ; Shimanouchi, Toshinori. / A planar-type leakage current and impedance microsensor for detection of interaction between electrolyte-entrapping liposome and protein. IMFEDK 2012 - 2012 International Meeting for Future of Electron Devices, Kansai. 2012. pp. 146-147
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