A pilot study: Effects of dietary supplementation with α-linolenic acid-enriched perilla seed oil on bronchial asthma

Kozo Ashida, Fumihiro Mitsunobu, Takashi Mifune, Yasuhiro Hosaki, Satoshi Yokota, Hirofumi Tsugeno, Yoshiro Tanizaki, Takao Tsuji

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA), parent n-3 fatty acid, were studied in five patients with asthma. The symptoms of asthma and mean peak flow rates (PFR) both early in the morning and in the evening were improved 2 weeks after dietary supplementation and the increases in PFR were significant (P < 0.05). The generation of leukotriene B4(LTB4) by peripheral leukocytes stimulated with the Ca2+ionophore A23187 was significantly suppressed from 77.6 to 41.6ng/5X106cells by dietary supplementation (P< 0.05). The generation of leukotriene C4(LTC4) by leukocytes was also significantly suppressed from 64.0 to 38.8 ng/5x106cells after supplementation with perilla seed oil (P < 0.05). These results suggest that dietary supplementation with perilla seed oil is beneficial for the treatment of asthma.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalAllergology International
Volume46
Issue number3
DOIs
Publication statusPublished - 1997

Keywords

  • bronchial asthma
  • leukotriene B
  • leukotriene C
  • peak flow
  • perilla seed oil

ASJC Scopus subject areas

  • Immunology and Allergy

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