A phase II clinical trial of the efficacy and safety of short-term (3 days) enoxaparin for the prevention of venous thromboembolism after gastric cancer surgery

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Abstract

Although intermittent pneumatic compression (IPC) has become common as perioperative prophylaxis for venous thromboembolism (VTE) consisting of pulmonary thromboembolism (PE) and deep vein thrombosis (DVT), the prophylactic effect against VTE, especially lethal PE, is not yet satisfactory. Therefore, pharmacologic prophylaxis, such as with enoxaparin, is desirable. While the efficacy and safety of enoxaparin have been proven in several clinical trials, concern about bleeding with longterm (at least 7 days) use have potentially decreased its widespread adoption. We have launched a phase II study to evaluate the efficacy and safety of short-term (3 days) enoxaparin, in which a total of 70 gastric cancer patients undergoing gastrectomy will be recruited, and the primary endpoint is the incidence of DVT. This study could contribute to making pharmacologic prophylaxis for VTE more common.

Original languageEnglish
Pages (from-to)401-404
Number of pages4
JournalActa Medica Okayama
Volume70
Issue number5
Publication statusPublished - 2016

Keywords

  • Enoxaparin
  • Gastric cancer
  • Short-term use
  • Surgery
  • Venous thromboembolism

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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