A Patient with Type 3 Autoimmune Polyglandular Syndrome who Developed Systemic Lupus Erythematosus 8 years after the Diagnosis of Autoimmune Hepatitis

Tomoyo Mifune-Morioka, Haruhito Adam Uchida, Kazuhiko Fukushima, Mayu Watanabe, Chihiro Ouchi, Koki Mise, Chieko Kawakita, Yuzuki Kano, Akifumi Onishi, Kishio Toma, Jun Eguchi, Nozomu Wada, Fusao Ikeda, Erika Sasaki, Yu Suganami, Masayuki Kishida, Hitoshi Sugiyama, Hiroyuki Okada, Jun Wada

Research output: Contribution to journalArticle

Abstract

Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.

Original languageEnglish
Pages (from-to)367-372
Number of pages6
JournalActa medica Okayama
Volume73
Issue number4
DOIs
Publication statusPublished - Aug 1 2019

Fingerprint

Autoimmune Polyendocrinopathies
Autoimmune Hepatitis
Prednisolone
Systemic Lupus Erythematosus
Medical problems
Type 1 Diabetes Mellitus
Cyclophosphamide
Autoimmune Diseases
Insulin
Therapeutics

Keywords

  • autoimmune hepatitis
  • autoimmune polyglandular syndrome type 3
  • chronic thyroiditis
  • slowly progressive insulin-dependent diabetes mellitus
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

A Patient with Type 3 Autoimmune Polyglandular Syndrome who Developed Systemic Lupus Erythematosus 8 years after the Diagnosis of Autoimmune Hepatitis. / Mifune-Morioka, Tomoyo; Uchida, Haruhito Adam; Fukushima, Kazuhiko; Watanabe, Mayu; Ouchi, Chihiro; Mise, Koki; Kawakita, Chieko; Kano, Yuzuki; Onishi, Akifumi; Toma, Kishio; Eguchi, Jun; Wada, Nozomu; Ikeda, Fusao; Sasaki, Erika; Suganami, Yu; Kishida, Masayuki; Sugiyama, Hitoshi; Okada, Hiroyuki; Wada, Jun.

In: Acta medica Okayama, Vol. 73, No. 4, 01.08.2019, p. 367-372.

Research output: Contribution to journalArticle

Mifune-Morioka, Tomoyo ; Uchida, Haruhito Adam ; Fukushima, Kazuhiko ; Watanabe, Mayu ; Ouchi, Chihiro ; Mise, Koki ; Kawakita, Chieko ; Kano, Yuzuki ; Onishi, Akifumi ; Toma, Kishio ; Eguchi, Jun ; Wada, Nozomu ; Ikeda, Fusao ; Sasaki, Erika ; Suganami, Yu ; Kishida, Masayuki ; Sugiyama, Hitoshi ; Okada, Hiroyuki ; Wada, Jun. / A Patient with Type 3 Autoimmune Polyglandular Syndrome who Developed Systemic Lupus Erythematosus 8 years after the Diagnosis of Autoimmune Hepatitis. In: Acta medica Okayama. 2019 ; Vol. 73, No. 4. pp. 367-372.
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