A patient with anti-aquaporin 4 antibody presenting hypersomnolence as the initial symptom and symmetrical hypothalamic lesions

Kentaro Deguchi, Syoichiro Kono, Shoko Deguchi, Nobutoshi Morimoto, Masami Ikeda, Tomoko Kurata, Yoshio Ikeda, Tohru Matsuura, Takashi Kanbayashi, Toshiyuki Takahashi, Koji Abe

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Here we report a case with positive serum anti-aquaporin 4 (AQP4) antibody who presented with hypersomnolence, symmetrical hypothalamic lesions and a reduced CSF orexin (hypocretin) level without optic nerve and spinal cord lesions on MRI. All of the symptoms, MRI finding and CSF orexin level improved simultaneously after steroid therapy. AQP4 is a member of the AQP superfamily which is strongly expressed in the hypothalamus where orexin (hypocretin)-containing neurons are primarily concentrated. Although there have been only a few reports similar to our case, the present case suggests a close relationship between the positive serum anti-AQP4 antibody and symmetrical hypothalamic lesions with hypersomnolence and without optic /spinal lesion, which is improved by steroid treatment.

Original languageEnglish
Pages (from-to)18-20
Number of pages3
JournalJournal of the neurological sciences
Volume312
Issue number1-2
DOIs
Publication statusPublished - Jan 15 2012

Keywords

  • Aquaporin 4
  • Hypersomnolence
  • Neuromyelitis optica
  • Symmetrical hypothalamic lesions

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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