A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred strain of mice

A. Wada, Tetsuo Kunieda, M. Nishimura, Y. Kakizoe-Ishida, N. Watanabe, K. Ohkawa, M. Tsudzuki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

"Tawny" is an autosomal recessive coat color mutation found in a wild population of Mus musculus molossinus. The inbred strain MSKR carries the mutation. The causative gene Mc1rtaw of the tawny phenotype is the second recessive allele at the melanocortin I receptor locus and is dominant to the first recessive allele, "recessive yellow" (Mc1re). The Mc1rtaw gene has six nucleotide substitutions, and its forecasted transcript has three amino acid substitutions (i.e., V101A, V216A, W252C). Though the nucleotide substitutions leading to V101A and V216A exist in various mouse strains, the nucleotide substitution leading to W252C exists in only tawny-colored mice. Thus this substitution is considered to be responsible for the expression of the tawny coat color. The frequency of the allele having this nucleotide substitution was 9.21% in the wild M. m. molossinus population inhabiting Sakai City, Osaka Prefecture, Japan, where the ancestral mice of the MSKR strain were captured.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalJournal of Heredity
Volume96
Issue number2
DOIs
Publication statusPublished - Mar 2005

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Inbred Strains Mice
Nucleotides
Color
nucleotides
mutation
Mutation
color
mice
Alleles
Melanocortin Receptors
alleles
amino acid substitution
Mus musculus
Amino Acid Substitution
Gene Frequency
Population
Genes
gene frequency
Japan
genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred strain of mice. / Wada, A.; Kunieda, Tetsuo; Nishimura, M.; Kakizoe-Ishida, Y.; Watanabe, N.; Ohkawa, K.; Tsudzuki, M.

In: Journal of Heredity, Vol. 96, No. 2, 03.2005, p. 145-149.

Research output: Contribution to journalArticle

Wada, A. ; Kunieda, Tetsuo ; Nishimura, M. ; Kakizoe-Ishida, Y. ; Watanabe, N. ; Ohkawa, K. ; Tsudzuki, M. / A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred strain of mice. In: Journal of Heredity. 2005 ; Vol. 96, No. 2. pp. 145-149.
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AU - Wada, A.

AU - Kunieda, Tetsuo

AU - Nishimura, M.

AU - Kakizoe-Ishida, Y.

AU - Watanabe, N.

AU - Ohkawa, K.

AU - Tsudzuki, M.

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N2 - "Tawny" is an autosomal recessive coat color mutation found in a wild population of Mus musculus molossinus. The inbred strain MSKR carries the mutation. The causative gene Mc1rtaw of the tawny phenotype is the second recessive allele at the melanocortin I receptor locus and is dominant to the first recessive allele, "recessive yellow" (Mc1re). The Mc1rtaw gene has six nucleotide substitutions, and its forecasted transcript has three amino acid substitutions (i.e., V101A, V216A, W252C). Though the nucleotide substitutions leading to V101A and V216A exist in various mouse strains, the nucleotide substitution leading to W252C exists in only tawny-colored mice. Thus this substitution is considered to be responsible for the expression of the tawny coat color. The frequency of the allele having this nucleotide substitution was 9.21% in the wild M. m. molossinus population inhabiting Sakai City, Osaka Prefecture, Japan, where the ancestral mice of the MSKR strain were captured.

AB - "Tawny" is an autosomal recessive coat color mutation found in a wild population of Mus musculus molossinus. The inbred strain MSKR carries the mutation. The causative gene Mc1rtaw of the tawny phenotype is the second recessive allele at the melanocortin I receptor locus and is dominant to the first recessive allele, "recessive yellow" (Mc1re). The Mc1rtaw gene has six nucleotide substitutions, and its forecasted transcript has three amino acid substitutions (i.e., V101A, V216A, W252C). Though the nucleotide substitutions leading to V101A and V216A exist in various mouse strains, the nucleotide substitution leading to W252C exists in only tawny-colored mice. Thus this substitution is considered to be responsible for the expression of the tawny coat color. The frequency of the allele having this nucleotide substitution was 9.21% in the wild M. m. molossinus population inhabiting Sakai City, Osaka Prefecture, Japan, where the ancestral mice of the MSKR strain were captured.

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