Abstract
"Tawny" is an autosomal recessive coat color mutation found in a wild population of Mus musculus molossinus. The inbred strain MSKR carries the mutation. The causative gene Mc1rtaw of the tawny phenotype is the second recessive allele at the melanocortin I receptor locus and is dominant to the first recessive allele, "recessive yellow" (Mc1re). The Mc1rtaw gene has six nucleotide substitutions, and its forecasted transcript has three amino acid substitutions (i.e., V101A, V216A, W252C). Though the nucleotide substitutions leading to V101A and V216A exist in various mouse strains, the nucleotide substitution leading to W252C exists in only tawny-colored mice. Thus this substitution is considered to be responsible for the expression of the tawny coat color. The frequency of the allele having this nucleotide substitution was 9.21% in the wild M. m. molossinus population inhabiting Sakai City, Osaka Prefecture, Japan, where the ancestral mice of the MSKR strain were captured.
| Original language | English |
|---|---|
| Pages (from-to) | 145-149 |
| Number of pages | 5 |
| Journal | Journal of Heredity |
| Volume | 96 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 2005 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Genetics
- Genetics(clinical)
Cite this
A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred strain of mice. / Wada, A.; Kunieda, Tetsuo; Nishimura, M.; Kakizoe-Ishida, Y.; Watanabe, N.; Ohkawa, K.; Tsudzuki, M.
In: Journal of Heredity, Vol. 96, No. 2, 03.2005, p. 145-149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred strain of mice
AU - Wada, A.
AU - Kunieda, Tetsuo
AU - Nishimura, M.
AU - Kakizoe-Ishida, Y.
AU - Watanabe, N.
AU - Ohkawa, K.
AU - Tsudzuki, M.
PY - 2005/3
Y1 - 2005/3
N2 - "Tawny" is an autosomal recessive coat color mutation found in a wild population of Mus musculus molossinus. The inbred strain MSKR carries the mutation. The causative gene Mc1rtaw of the tawny phenotype is the second recessive allele at the melanocortin I receptor locus and is dominant to the first recessive allele, "recessive yellow" (Mc1re). The Mc1rtaw gene has six nucleotide substitutions, and its forecasted transcript has three amino acid substitutions (i.e., V101A, V216A, W252C). Though the nucleotide substitutions leading to V101A and V216A exist in various mouse strains, the nucleotide substitution leading to W252C exists in only tawny-colored mice. Thus this substitution is considered to be responsible for the expression of the tawny coat color. The frequency of the allele having this nucleotide substitution was 9.21% in the wild M. m. molossinus population inhabiting Sakai City, Osaka Prefecture, Japan, where the ancestral mice of the MSKR strain were captured.
AB - "Tawny" is an autosomal recessive coat color mutation found in a wild population of Mus musculus molossinus. The inbred strain MSKR carries the mutation. The causative gene Mc1rtaw of the tawny phenotype is the second recessive allele at the melanocortin I receptor locus and is dominant to the first recessive allele, "recessive yellow" (Mc1re). The Mc1rtaw gene has six nucleotide substitutions, and its forecasted transcript has three amino acid substitutions (i.e., V101A, V216A, W252C). Though the nucleotide substitutions leading to V101A and V216A exist in various mouse strains, the nucleotide substitution leading to W252C exists in only tawny-colored mice. Thus this substitution is considered to be responsible for the expression of the tawny coat color. The frequency of the allele having this nucleotide substitution was 9.21% in the wild M. m. molossinus population inhabiting Sakai City, Osaka Prefecture, Japan, where the ancestral mice of the MSKR strain were captured.
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U2 - 10.1093/jhered/esi022
DO - 10.1093/jhered/esi022
M3 - Article
VL - 96
SP - 145
EP - 149
JO - Journal of Heredity
JF - Journal of Heredity
SN - 0022-1503
IS - 2
ER -