TY - JOUR
T1 - A novel useful tool of computerized touch panel-type screening test for evaluating cognitive function of chronic ischemic stroke patients
AU - Deguchi, Kentaro
AU - Kono, Syoichiro
AU - Deguchi, Shoko
AU - Morimoto, Nobutoshi
AU - Kurata, Tomoko
AU - Ikeda, Yoshio
AU - Abe, Koji
N1 - Funding Information:
This work was partly supported by Grants-in-Aid for Scientific Research (B) 21390267 and Young Scientists (B) 23790991 and the Ministry of Education, Culture, Sports, Science, and Technology of Japan , and by Grants-in-Aid from the Research Committee of Central Nervous System Degenerative Diseases , and grants from the Ministry of Health, Labor, and Welfare of Japan .
PY - 2013/10
Y1 - 2013/10
N2 - Cognitive and affective impairments are important non-motor features of ischemic stroke (IS) related to white-matter hyperintensity, including periventricular hyperintensity (PVH). To confirm the usefulness of a novel computerized touch panel-type screening test, we investigated cognitive and affective functioning among 142 IS patients and 105 age-and gender-matched normal control subjects. Assessment using the mini-mental state examination, Hasegawa Dementia Scale-Revised, and frontal assessment battery revealed reduced cognitive function in IS patients, with the most severe reduction exhibited by cardiogenic embolism patients, followed by lacunar infarction patients, and atherothrombotic infarction patients. Our novel touch panel screening test revealed a similar pattern of results. In addition, PVH grading, classified using Fazekas' magnetic resonance imaging method, was also correlated with cognitive decline and touch panel screening test performance. In contrast, affective function, assessed with the 15-item Geriatric Depression Scale, vitality index, and apathy scale, was not significantly decreased in IS, and did not correlate with touch panel screening test results or PVH, although the number of microbleeds was correlated with apathy scale results. The present findings revealed that IS and PVH grading were significantly correlated with decline in general cognitive status (mini-mental state examination and Hasegawa Dementia Scale-Revised) and frontal lobe function (frontal assessment battery). Performance on all touch panel screening tests was correlated with IS and PVH grading, but was largely independent of depression or apathy. Touch panel screening tests were easily understood and performed by almost all patients with mild cognitive and motor dysfunction, due to visually clear images and simple methods not involving detailed manual-handling tasks such as writing. Touch panel screening tests may provide a useful tool for the early screening of cognitive function.
AB - Cognitive and affective impairments are important non-motor features of ischemic stroke (IS) related to white-matter hyperintensity, including periventricular hyperintensity (PVH). To confirm the usefulness of a novel computerized touch panel-type screening test, we investigated cognitive and affective functioning among 142 IS patients and 105 age-and gender-matched normal control subjects. Assessment using the mini-mental state examination, Hasegawa Dementia Scale-Revised, and frontal assessment battery revealed reduced cognitive function in IS patients, with the most severe reduction exhibited by cardiogenic embolism patients, followed by lacunar infarction patients, and atherothrombotic infarction patients. Our novel touch panel screening test revealed a similar pattern of results. In addition, PVH grading, classified using Fazekas' magnetic resonance imaging method, was also correlated with cognitive decline and touch panel screening test performance. In contrast, affective function, assessed with the 15-item Geriatric Depression Scale, vitality index, and apathy scale, was not significantly decreased in IS, and did not correlate with touch panel screening test results or PVH, although the number of microbleeds was correlated with apathy scale results. The present findings revealed that IS and PVH grading were significantly correlated with decline in general cognitive status (mini-mental state examination and Hasegawa Dementia Scale-Revised) and frontal lobe function (frontal assessment battery). Performance on all touch panel screening tests was correlated with IS and PVH grading, but was largely independent of depression or apathy. Touch panel screening tests were easily understood and performed by almost all patients with mild cognitive and motor dysfunction, due to visually clear images and simple methods not involving detailed manual-handling tasks such as writing. Touch panel screening tests may provide a useful tool for the early screening of cognitive function.
KW - Touch panel screening test
KW - cognitive and affective function
KW - microbleeds
KW - periventricular hyperintensity
UR - http://www.scopus.com/inward/record.url?scp=84886008513&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886008513&partnerID=8YFLogxK
U2 - 10.1016/j.jstrokecerebrovasdis.2012.11.011
DO - 10.1016/j.jstrokecerebrovasdis.2012.11.011
M3 - Article
C2 - 23290436
AN - SCOPUS:84886008513
VL - 22
SP - e197-e206
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
SN - 1052-3057
IS - 7
ER -