A novel tumor suppressor, REIC/Dkk-3 gene identified by our in vitro transformation model of normal human fibroblasts works as a potent therapeutic anti-tumor agent

Masakiyo Sakaguchi; Nam Ho Huh; Masayoshi Namba

doi:10.1007/978-1-4614-0254-1_17

A novel tumor suppressor, REIC/Dkk-3 gene identified by our in vitro transformation model of normal human fibroblasts works as a potent therapeutic anti-tumor agent

Masakiyo Sakaguchi, Nam Ho Huh, Masayoshi Namba

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Citations (Scopus)

Abstract

Reduced Expression in Immortalized Cell (REIC) was cloned by subtractive hybridization method as a gene whose expression is reduced in many human immortalized and neoplastic tumor cells. The REIC, when over-expressed by an adenovirus (Ad-REIC), exhibited a dramatic therapeutic effect on a wide variety of human cancers through a mechanism triggered by ER-stress-mediated JNK activation. In addition to this direct effect on cancer cells, Ad-REIC exerted another cytotoxicity on human cancers, an indirect host-mediated effect due to overproduction of IL-7 by mis-targeted normal cells. This "one-bullet two-arms" finding may lead to a powerful new therapeutic approach to the treatment of human cancers.

Original language	English
Title of host publication	Human Cell Transformation
Subtitle of host publication	Role of Stem Cells and the Microenvironment
Editors	Johng Rhim, Richard Kremer
Pages	209-215
Number of pages	7
DOIs	https://doi.org/10.1007/978-1-4614-0254-1_17
Publication status	Published - 2011

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	720
ISSN (Print)	0065-2598

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-1-4614-0254-1_17

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Sakaguchi, M., Huh, N. H., & Namba, M. (2011). A novel tumor suppressor, REIC/Dkk-3 gene identified by our in vitro transformation model of normal human fibroblasts works as a potent therapeutic anti-tumor agent. In J. Rhim, & R. Kremer (Eds.), Human Cell Transformation: Role of Stem Cells and the Microenvironment (pp. 209-215). (Advances in Experimental Medicine and Biology; Vol. 720). https://doi.org/10.1007/978-1-4614-0254-1_17

A novel tumor suppressor, REIC/Dkk-3 gene identified by our in vitro transformation model of normal human fibroblasts works as a potent therapeutic anti-tumor agent. / Sakaguchi, Masakiyo; Huh, Nam Ho; Namba, Masayoshi.

Human Cell Transformation: Role of Stem Cells and the Microenvironment. ed. / Johng Rhim; Richard Kremer. 2011. p. 209-215 (Advances in Experimental Medicine and Biology; Vol. 720).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sakaguchi, M, Huh, NH & Namba, M 2011, A novel tumor suppressor, REIC/Dkk-3 gene identified by our in vitro transformation model of normal human fibroblasts works as a potent therapeutic anti-tumor agent. in J Rhim & R Kremer (eds), Human Cell Transformation: Role of Stem Cells and the Microenvironment. Advances in Experimental Medicine and Biology, vol. 720, pp. 209-215. https://doi.org/10.1007/978-1-4614-0254-1_17

Sakaguchi M, Huh NH, Namba M. A novel tumor suppressor, REIC/Dkk-3 gene identified by our in vitro transformation model of normal human fibroblasts works as a potent therapeutic anti-tumor agent. In Rhim J, Kremer R, editors, Human Cell Transformation: Role of Stem Cells and the Microenvironment. 2011. p. 209-215. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-0254-1_17

Sakaguchi, Masakiyo ; Huh, Nam Ho ; Namba, Masayoshi. / A novel tumor suppressor, REIC/Dkk-3 gene identified by our in vitro transformation model of normal human fibroblasts works as a potent therapeutic anti-tumor agent. Human Cell Transformation: Role of Stem Cells and the Microenvironment. editor / Johng Rhim ; Richard Kremer. 2011. pp. 209-215 (Advances in Experimental Medicine and Biology).

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