TY - GEN
T1 - A novel tumor suppressor, REIC/Dkk-3 gene identified by our in vitro transformation model of normal human fibroblasts works as a potent therapeutic anti-tumor agent
AU - Sakaguchi, Masakiyo
AU - Huh, Nam Ho
AU - Namba, Masayoshi
PY - 2011
Y1 - 2011
N2 - Reduced Expression in Immortalized Cell (REIC) was cloned by subtractive hybridization method as a gene whose expression is reduced in many human immortalized and neoplastic tumor cells. The REIC, when over-expressed by an adenovirus (Ad-REIC), exhibited a dramatic therapeutic effect on a wide variety of human cancers through a mechanism triggered by ER-stress-mediated JNK activation. In addition to this direct effect on cancer cells, Ad-REIC exerted another cytotoxicity on human cancers, an indirect host-mediated effect due to overproduction of IL-7 by mis-targeted normal cells. This "one-bullet two-arms" finding may lead to a powerful new therapeutic approach to the treatment of human cancers.
AB - Reduced Expression in Immortalized Cell (REIC) was cloned by subtractive hybridization method as a gene whose expression is reduced in many human immortalized and neoplastic tumor cells. The REIC, when over-expressed by an adenovirus (Ad-REIC), exhibited a dramatic therapeutic effect on a wide variety of human cancers through a mechanism triggered by ER-stress-mediated JNK activation. In addition to this direct effect on cancer cells, Ad-REIC exerted another cytotoxicity on human cancers, an indirect host-mediated effect due to overproduction of IL-7 by mis-targeted normal cells. This "one-bullet two-arms" finding may lead to a powerful new therapeutic approach to the treatment of human cancers.
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U2 - 10.1007/978-1-4614-0254-1_17
DO - 10.1007/978-1-4614-0254-1_17
M3 - Conference contribution
C2 - 21901630
AN - SCOPUS:80053905608
SN - 9781461402534
T3 - Advances in Experimental Medicine and Biology
SP - 209
EP - 215
BT - Human Cell Transformation
A2 - Rhim, Johng
A2 - Kremer, Richard
ER -