A novel tumor suppressor, REIC/Dkk-3 gene identified by our in vitro transformation model of normal human fibroblasts works as a potent therapeutic anti-tumor agent

Masakiyo Sakaguchi, Nam Ho Huh, Masayoshi Namba

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Reduced Expression in Immortalized Cell (REIC) was cloned by subtractive hybridization method as a gene whose expression is reduced in many human immortalized and neoplastic tumor cells. The REIC, when over-expressed by an adenovirus (Ad-REIC), exhibited a dramatic therapeutic effect on a wide variety of human cancers through a mechanism triggered by ER-stress-mediated JNK activation. In addition to this direct effect on cancer cells, Ad-REIC exerted another cytotoxicity on human cancers, an indirect host-mediated effect due to overproduction of IL-7 by mis-targeted normal cells. This "one-bullet two-arms" finding may lead to a powerful new therapeutic approach to the treatment of human cancers.

Original languageEnglish
Title of host publicationHuman Cell Transformation
Subtitle of host publicationRole of Stem Cells and the Microenvironment
EditorsJohng Rhim, Richard Kremer
Pages209-215
Number of pages7
DOIs
Publication statusPublished - 2011

Publication series

NameAdvances in Experimental Medicine and Biology
Volume720
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Sakaguchi, M., Huh, N. H., & Namba, M. (2011). A novel tumor suppressor, REIC/Dkk-3 gene identified by our in vitro transformation model of normal human fibroblasts works as a potent therapeutic anti-tumor agent. In J. Rhim, & R. Kremer (Eds.), Human Cell Transformation: Role of Stem Cells and the Microenvironment (pp. 209-215). (Advances in Experimental Medicine and Biology; Vol. 720). https://doi.org/10.1007/978-1-4614-0254-1_17