Abstract
Reduced Expression in Immortalized Cell (REIC) was cloned by subtractive hybridization method as a gene whose expression is reduced in many human immortalized and neoplastic tumor cells. The REIC, when over-expressed by an adenovirus (Ad-REIC), exhibited a dramatic therapeutic effect on a wide variety of human cancers through a mechanism triggered by ER-stress-mediated JNK activation. In addition to this direct effect on cancer cells, Ad-REIC exerted another cytotoxicity on human cancers, an indirect host-mediated effect due to overproduction of IL-7 by mis-targeted normal cells. This "one-bullet two-arms" finding may lead to a powerful new therapeutic approach to the treatment of human cancers.
| Original language | English |
|---|---|
| Title of host publication | Human Cell Transformation |
| Subtitle of host publication | Role of Stem Cells and the Microenvironment |
| Editors | Johng Rhim, Richard Kremer |
| Pages | 209-215 |
| Number of pages | 7 |
| DOIs | |
| Publication status | Published - 2011 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 720 |
| ISSN (Print) | 0065-2598 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Sakaguchi, M., Huh, N. H., & Namba, M. (2011). A novel tumor suppressor, REIC/Dkk-3 gene identified by our in vitro transformation model of normal human fibroblasts works as a potent therapeutic anti-tumor agent. In J. Rhim, & R. Kremer (Eds.), Human Cell Transformation: Role of Stem Cells and the Microenvironment (pp. 209-215). (Advances in Experimental Medicine and Biology; Vol. 720). https://doi.org/10.1007/978-1-4614-0254-1_17