Abstract
"Barbier Type" allylation of imines with allyl bromide has been performed successfully by the action of aluminum (1 equiv.) and titanium(IV)chloride (0.05 equiv.) in THF. The chirality transfer of α-amino acid esters to homoallyl amines is demonstrated by allylation of N-benzalvaline methyl ester followed by alkaline hydrolysis and electrolytic decarboxylation.
Original language | English |
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Pages (from-to) | 3023-3026 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 31 |
Issue number | 21 |
DOIs | |
Publication status | Published - 1990 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry