Abstract
A variety of optically active C2-symmetric pyridine derivatives have been prepared from L- or D-tartaric acid as a chiral source via efficient coupling reactions of triflates with 2-picolyllithium reagents, and the utility of 17 and 18 as chiral ligands in the catalytic enantioselective addition of diethylzinc to benzaldehyde has been demonstrated (up to 41% ee). The synthetic procedure for the corresponding meso-isomer was also described.
Original language | English |
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Pages (from-to) | 1165-1174 |
Number of pages | 10 |
Journal | Tetrahedron: Asymmetry |
Volume | 6 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- Catalysis
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry