A novel sequence found at the 3′-terminus of hepatitis C virus genome

Torahiko Tanaka, Nobuyuki Kato, Myung Je Cho, Kunitada Shimotohno

Research output: Contribution to journalArticlepeer-review

247 Citations (Scopus)


The 3′ end region of positive-strand RNA-virus genomes is implicated in the initiation of genomic replication. We analyzed the extreme 3′ end of the hepatitis C virus (HCV) genome by primer extension of the 5′ end region of the antigenomic strand RNA found in infected liver. We discovered a novel sequence present downstream of the poly(U) stretch that was previously considered to be the 3′ end structure of the HCV genome. The novel sequence was 98 nucleotides long and had no significant homology with any known sequences, viral or nonviral. The discovery of this novel tail on the HCV genome should contribute to the study of HCV replication.

Original languageEnglish
Pages (from-to)744-749
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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