A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner

Shinsuke Ohba, Keiji Nakajima, Yusuke Komiyama, Fumitaka Kugimiya, Kazuyo Igawa, Keiji Itaka, Toru Moro, Kozo Nakamura, Hiroshi Kawaguchi, Tsuyoshi Takato, Ung il Chung

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

To effectively treat serious bone defects using bone regenerative medicine, there is a need for the development of a small chemical compound that potently induces bone formation. We now report a novel osteogenic helioxanthin-derivative, TH. TH induced osteogenic differentiation in MC3T3-E1 cells, mouse primary osteoblasts, and mouse embryonic stem cells. The combination of TH and bone morphogenetic protein (BMP) 2 induced the mRNA expression of osteoblast marker genes and calcification in primary fibroblasts. The TH induced the mRNA of the inhibitor of DNA-binding 1 (Id-1), and its osteogenic effect was inhibited by Smad6 or Noggin. Furthermore, TH induced the mRNA expression of Bmp4 and Bmp6. These data suggest that TH exerts its potent osteogenic effect in a BMP-dependent manner by enhancing the effects of the existing BMPs and/or increasing the expression of Bmp4 and Bmp6. TH may help establish a more efficient bone regeneration system.

Original languageEnglish
Pages (from-to)854-860
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume357
Issue number4
DOIs
Publication statusPublished - Jun 15 2007
Externally publishedYes

Keywords

  • BMP
  • Bone regeneration
  • ES cell
  • Fibroblast
  • Osteoblast
  • Osteogenic differentiation
  • Small compound

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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