A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

Y. Hakata, S. Tsuchiya, Hiroyuki Michiue, Takashi Ohtsuki, Hideki Matsui, M. Miyazawa, M. Kitamatsu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A hybrid comprising an autophagy-inducing peptide (AIP) and a cell-penetrating peptide (CPP) connected via heterodimeric leucine zippers was generated and delivered into cells. The hybrid successfully induced autophagy without significant cell death, while the same AIP directly connected to a CPP caused both autophagy and significant cell death. This journal is

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalChemical Communications
Volume51
Issue number2
DOIs
Publication statusPublished - Jan 7 2015

Fingerprint

Cell-Penetrating Peptides
Leucine Zippers
Fasteners
Autophagy
Cell death
Peptides
Cell Death

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys
  • Medicine(all)

Cite this

A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells. / Hakata, Y.; Tsuchiya, S.; Michiue, Hiroyuki; Ohtsuki, Takashi; Matsui, Hideki; Miyazawa, M.; Kitamatsu, M.

In: Chemical Communications, Vol. 51, No. 2, 07.01.2015, p. 413-416.

Research output: Contribution to journalArticle

Hakata, Y. ; Tsuchiya, S. ; Michiue, Hiroyuki ; Ohtsuki, Takashi ; Matsui, Hideki ; Miyazawa, M. ; Kitamatsu, M. / A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells. In: Chemical Communications. 2015 ; Vol. 51, No. 2. pp. 413-416.
@article{cc6429760fca4fb6a1f50d4d198ad2d4,
title = "A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells",
abstract = "A hybrid comprising an autophagy-inducing peptide (AIP) and a cell-penetrating peptide (CPP) connected via heterodimeric leucine zippers was generated and delivered into cells. The hybrid successfully induced autophagy without significant cell death, while the same AIP directly connected to a CPP caused both autophagy and significant cell death. This journal is",
author = "Y. Hakata and S. Tsuchiya and Hiroyuki Michiue and Takashi Ohtsuki and Hideki Matsui and M. Miyazawa and M. Kitamatsu",
year = "2015",
month = "1",
day = "7",
doi = "10.1039/c4cc07459a",
language = "English",
volume = "51",
pages = "413--416",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "2",

}

TY - JOUR

T1 - A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

AU - Hakata, Y.

AU - Tsuchiya, S.

AU - Michiue, Hiroyuki

AU - Ohtsuki, Takashi

AU - Matsui, Hideki

AU - Miyazawa, M.

AU - Kitamatsu, M.

PY - 2015/1/7

Y1 - 2015/1/7

N2 - A hybrid comprising an autophagy-inducing peptide (AIP) and a cell-penetrating peptide (CPP) connected via heterodimeric leucine zippers was generated and delivered into cells. The hybrid successfully induced autophagy without significant cell death, while the same AIP directly connected to a CPP caused both autophagy and significant cell death. This journal is

AB - A hybrid comprising an autophagy-inducing peptide (AIP) and a cell-penetrating peptide (CPP) connected via heterodimeric leucine zippers was generated and delivered into cells. The hybrid successfully induced autophagy without significant cell death, while the same AIP directly connected to a CPP caused both autophagy and significant cell death. This journal is

UR - http://www.scopus.com/inward/record.url?scp=84916243974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84916243974&partnerID=8YFLogxK

U2 - 10.1039/c4cc07459a

DO - 10.1039/c4cc07459a

M3 - Article

C2 - 25406914

AN - SCOPUS:84916243974

VL - 51

SP - 413

EP - 416

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 2

ER -