A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

Y. Hakata, S. Tsuchiya, H. Michiue, T. Ohtsuki, H. Matsui, M. Miyazawa, M. Kitamatsu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A hybrid comprising an autophagy-inducing peptide (AIP) and a cell-penetrating peptide (CPP) connected via heterodimeric leucine zippers was generated and delivered into cells. The hybrid successfully induced autophagy without significant cell death, while the same AIP directly connected to a CPP caused both autophagy and significant cell death. This journal is

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalChemical Communications
Volume51
Issue number2
DOIs
Publication statusPublished - Jan 7 2015

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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