A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

Y. Hakata; S. Tsuchiya; H. Michiue; T. Ohtsuki; Hideki Matsui; M. Miyazawa; M. Kitamatsu

doi:10.1039/c4cc07459a

A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

Y. Hakata, S. Tsuchiya, H. Michiue, T. Ohtsuki, Hideki Matsui, M. Miyazawa, M. Kitamatsu

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A hybrid comprising an autophagy-inducing peptide (AIP) and a cell-penetrating peptide (CPP) connected via heterodimeric leucine zippers was generated and delivered into cells. The hybrid successfully induced autophagy without significant cell death, while the same AIP directly connected to a CPP caused both autophagy and significant cell death. This journal is

Original language	English
Pages (from-to)	413-416
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	2
DOIs	https://doi.org/10.1039/c4cc07459a
Publication status	Published - Jan 7 2015

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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AU - Matsui, Hideki

AU - Miyazawa, M.

AU - Kitamatsu, M.

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A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

Abstract

ASJC Scopus subject areas

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