A novel labdane-type trialdehyde from myoga (Zingiber mioga Roscoe) that potently inhibits human platelet aggregation and human 5-lipoxygenase

Masako Abe, Yoshio Ozawa, Yasushi Uda, Yasujiro Morimitsu, Yoshimasa Nakamura, Toshihiko Osawa

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

We screened myoga extracts for inhibitors of human platelet aggregation and human 5-lipoxygenase. We identified a novel labdane type of diterpene, together with three known diterpenes (miogadial and galanals A and B) from the flower buds of myoga. Spectroscopic data indicated the structure of the new compound to be 12(E)-labdene-15,16,(8β)17-trial (miogatrial). Miogatrial and miogadial were potent inhibitors of human platelet aggregation and human 5-lipoxygenase (5-LOX). The sesquiterpene, polygodial, also exhibited strong inhibitory activity against human platelet aggregation and 5-LOX. On the other hand, galanals A and B did not have inhibitory activity in either experimental system. It thus appears that a 3-formyl-3-butenal structure was essential for the potent inhibition of human platelet aggregation and human 5-LOX.

Original languageEnglish
Pages (from-to)2494-2500
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Volume70
Issue number10
DOIs
Publication statusPublished - Nov 6 2006

Keywords

  • 5-lipoxygenase
  • Labdane-type diterpene
  • Platelet aggregation
  • Polygodial
  • Zingiber mioga Roscoe

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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