A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells

Hideki Nakagoshi, Minako Hoshi, Yo Ichi Nabeshima, Fumio Matsuzaki

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Morphogen gradients of secreted molecules play critical roles in the establishment of the spatial pattern of gene expression. During midgut development in Drosophila, secreted molecules of Decapentaplegic (Dpp) and Wingless (Wg) establish unique transcriptional regulation within target cells to specify the resultant cell types. Here we report the identification of a novel homeobox gene, defective proventriculus (dve), which is required for the midgut specification under the control of Dpp and Wg. In dve mutants, two distinct parts of the midgut, the proventriculus and middle midgut, are abnormally organized. The Wg signal regulates dye expression during proventriculus development. On the other hand, dye is a downstream target of Dpp in the middle midgut and defines the functional specificity of copper cells along with another Dpp target gene, labial. Thus, the dve gene acts under the two distinct extracellular signals at distant parts of the midgut primordia.

Original languageEnglish
Pages (from-to)2724-2734
Number of pages11
JournalGenes and Development
Volume12
Issue number17
Publication statusPublished - Sep 1 1998
Externally publishedYes

Fingerprint

Proventriculus
Homeobox Genes
Coloring Agents
Lip
Genes
Drosophila
Copper
Gene Expression

Keywords

  • Dpp
  • Functional specificity
  • Homeodomain
  • Midgut
  • Wg

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells. / Nakagoshi, Hideki; Hoshi, Minako; Nabeshima, Yo Ichi; Matsuzaki, Fumio.

In: Genes and Development, Vol. 12, No. 17, 01.09.1998, p. 2724-2734.

Research output: Contribution to journalArticle

Nakagoshi, Hideki ; Hoshi, Minako ; Nabeshima, Yo Ichi ; Matsuzaki, Fumio. / A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells. In: Genes and Development. 1998 ; Vol. 12, No. 17. pp. 2724-2734.
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