Abstract
Morphogen gradients of secreted molecules play critical roles in the establishment of the spatial pattern of gene expression. During midgut development in Drosophila, secreted molecules of Decapentaplegic (Dpp) and Wingless (Wg) establish unique transcriptional regulation within target cells to specify the resultant cell types. Here we report the identification of a novel homeobox gene, defective proventriculus (dve), which is required for the midgut specification under the control of Dpp and Wg. In dve mutants, two distinct parts of the midgut, the proventriculus and middle midgut, are abnormally organized. The Wg signal regulates dye expression during proventriculus development. On the other hand, dye is a downstream target of Dpp in the middle midgut and defines the functional specificity of copper cells along with another Dpp target gene, labial. Thus, the dve gene acts under the two distinct extracellular signals at distant parts of the midgut primordia.
| Original language | English |
|---|---|
| Pages (from-to) | 2724-2734 |
| Number of pages | 11 |
| Journal | Genes and Development |
| Volume | 12 |
| Issue number | 17 |
| Publication status | Published - Sep 1 1998 |
| Externally published | Yes |
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Keywords
- Dpp
- Functional specificity
- Homeodomain
- Midgut
- Wg
ASJC Scopus subject areas
- Genetics
- Developmental Biology
Cite this
A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells. / Nakagoshi, Hideki; Hoshi, Minako; Nabeshima, Yo Ichi; Matsuzaki, Fumio.
In: Genes and Development, Vol. 12, No. 17, 01.09.1998, p. 2724-2734.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells
AU - Nakagoshi, Hideki
AU - Hoshi, Minako
AU - Nabeshima, Yo Ichi
AU - Matsuzaki, Fumio
PY - 1998/9/1
Y1 - 1998/9/1
N2 - Morphogen gradients of secreted molecules play critical roles in the establishment of the spatial pattern of gene expression. During midgut development in Drosophila, secreted molecules of Decapentaplegic (Dpp) and Wingless (Wg) establish unique transcriptional regulation within target cells to specify the resultant cell types. Here we report the identification of a novel homeobox gene, defective proventriculus (dve), which is required for the midgut specification under the control of Dpp and Wg. In dve mutants, two distinct parts of the midgut, the proventriculus and middle midgut, are abnormally organized. The Wg signal regulates dye expression during proventriculus development. On the other hand, dye is a downstream target of Dpp in the middle midgut and defines the functional specificity of copper cells along with another Dpp target gene, labial. Thus, the dve gene acts under the two distinct extracellular signals at distant parts of the midgut primordia.
AB - Morphogen gradients of secreted molecules play critical roles in the establishment of the spatial pattern of gene expression. During midgut development in Drosophila, secreted molecules of Decapentaplegic (Dpp) and Wingless (Wg) establish unique transcriptional regulation within target cells to specify the resultant cell types. Here we report the identification of a novel homeobox gene, defective proventriculus (dve), which is required for the midgut specification under the control of Dpp and Wg. In dve mutants, two distinct parts of the midgut, the proventriculus and middle midgut, are abnormally organized. The Wg signal regulates dye expression during proventriculus development. On the other hand, dye is a downstream target of Dpp in the middle midgut and defines the functional specificity of copper cells along with another Dpp target gene, labial. Thus, the dve gene acts under the two distinct extracellular signals at distant parts of the midgut primordia.
KW - Dpp
KW - Functional specificity
KW - Homeodomain
KW - Midgut
KW - Wg
UR - http://www.scopus.com/inward/record.url?scp=0032167471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032167471&partnerID=8YFLogxK
M3 - Article
C2 - 9732270
AN - SCOPUS:0032167471
VL - 12
SP - 2724
EP - 2734
JO - Genes and Development
JF - Genes and Development
SN - 0890-9369
IS - 17
ER -