A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13)

Kensuke Kojima, Kinuyo Kaneda, Chikamasa Yoshida, Hirokata Dansako, Nobuharu Fujii, Tomofumi Yano, Katsuji Shinagawa, Masaki Yasukawa, Shigeru Fujita, Mitsune Tanimoto

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We report a case of therapy-related myelodysplastic syndrome (t-MDS) with t(10;16)(q22;p13), in which novel fusion transcripts of the MORF and CBP genes were detected. In one MORF-CBP fusion transcript, exon 15 of the MORF gene was fused in frame with exon 5 of the CBP gene. In a reciprocal CBP-MORF transcript, exon 4 of the CBP gene was fused in frame with exon 16 of the MORF gene. This is the first reported case of t-MDS associated with t(10;16), and provides molecular evidence that the novel MORF-CBP and/or CBP-MORF fusion protein(s) might play an important role in the development of t-MDS.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalBritish Journal of Haematology
Volume120
Issue number2
DOIs
Publication statusPublished - Jan 2003

Keywords

  • CREB binding protein gene
  • Monocytic leukaemia zinc finger protein-related factor gene
  • Therapy-related myelodysplastic syndrome
  • Translocation (10;16)

ASJC Scopus subject areas

  • Hematology

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