A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13)

Kensuke Kojima, Kinuyo Kaneda, Chikamasa Yoshida, Hiromichi Dansako, Nobuharu Fujii, Tomofumi Yano, Katsuji Shinagawa, Masaki Yasukawa, Shigeru Fujita, Mitsune Tanimoto

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We report a case of therapy-related myelodysplastic syndrome (t-MDS) with t(10;16)(q22;p13), in which novel fusion transcripts of the MORF and CBP genes were detected. In one MORF-CBP fusion transcript, exon 15 of the MORF gene was fused in frame with exon 5 of the CBP gene. In a reciprocal CBP-MORF transcript, exon 4 of the CBP gene was fused in frame with exon 16 of the MORF gene. This is the first reported case of t-MDS associated with t(10;16), and provides molecular evidence that the novel MORF-CBP and/or CBP-MORF fusion protein(s) might play an important role in the development of t-MDS.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalBritish Journal of Haematology
Volume120
Issue number2
DOIs
Publication statusPublished - Jan 2003

Fingerprint

Myelodysplastic Syndromes
Exons
Genes
Therapeutics
Proteins

Keywords

  • CREB binding protein gene
  • Monocytic leukaemia zinc finger protein-related factor gene
  • Therapy-related myelodysplastic syndrome
  • Translocation (10;16)

ASJC Scopus subject areas

  • Hematology

Cite this

A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13). / Kojima, Kensuke; Kaneda, Kinuyo; Yoshida, Chikamasa; Dansako, Hiromichi; Fujii, Nobuharu; Yano, Tomofumi; Shinagawa, Katsuji; Yasukawa, Masaki; Fujita, Shigeru; Tanimoto, Mitsune.

In: British Journal of Haematology, Vol. 120, No. 2, 01.2003, p. 271-273.

Research output: Contribution to journalArticle

Kojima, Kensuke ; Kaneda, Kinuyo ; Yoshida, Chikamasa ; Dansako, Hiromichi ; Fujii, Nobuharu ; Yano, Tomofumi ; Shinagawa, Katsuji ; Yasukawa, Masaki ; Fujita, Shigeru ; Tanimoto, Mitsune. / A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13). In: British Journal of Haematology. 2003 ; Vol. 120, No. 2. pp. 271-273.
@article{38805e8b264d416e9eccc9367950b68b,
title = "A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13)",
abstract = "We report a case of therapy-related myelodysplastic syndrome (t-MDS) with t(10;16)(q22;p13), in which novel fusion transcripts of the MORF and CBP genes were detected. In one MORF-CBP fusion transcript, exon 15 of the MORF gene was fused in frame with exon 5 of the CBP gene. In a reciprocal CBP-MORF transcript, exon 4 of the CBP gene was fused in frame with exon 16 of the MORF gene. This is the first reported case of t-MDS associated with t(10;16), and provides molecular evidence that the novel MORF-CBP and/or CBP-MORF fusion protein(s) might play an important role in the development of t-MDS.",
keywords = "CREB binding protein gene, Monocytic leukaemia zinc finger protein-related factor gene, Therapy-related myelodysplastic syndrome, Translocation (10;16)",
author = "Kensuke Kojima and Kinuyo Kaneda and Chikamasa Yoshida and Hiromichi Dansako and Nobuharu Fujii and Tomofumi Yano and Katsuji Shinagawa and Masaki Yasukawa and Shigeru Fujita and Mitsune Tanimoto",
year = "2003",
month = "1",
doi = "10.1046/j.1365-2141.2003.04059.x",
language = "English",
volume = "120",
pages = "271--273",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13)

AU - Kojima, Kensuke

AU - Kaneda, Kinuyo

AU - Yoshida, Chikamasa

AU - Dansako, Hiromichi

AU - Fujii, Nobuharu

AU - Yano, Tomofumi

AU - Shinagawa, Katsuji

AU - Yasukawa, Masaki

AU - Fujita, Shigeru

AU - Tanimoto, Mitsune

PY - 2003/1

Y1 - 2003/1

N2 - We report a case of therapy-related myelodysplastic syndrome (t-MDS) with t(10;16)(q22;p13), in which novel fusion transcripts of the MORF and CBP genes were detected. In one MORF-CBP fusion transcript, exon 15 of the MORF gene was fused in frame with exon 5 of the CBP gene. In a reciprocal CBP-MORF transcript, exon 4 of the CBP gene was fused in frame with exon 16 of the MORF gene. This is the first reported case of t-MDS associated with t(10;16), and provides molecular evidence that the novel MORF-CBP and/or CBP-MORF fusion protein(s) might play an important role in the development of t-MDS.

AB - We report a case of therapy-related myelodysplastic syndrome (t-MDS) with t(10;16)(q22;p13), in which novel fusion transcripts of the MORF and CBP genes were detected. In one MORF-CBP fusion transcript, exon 15 of the MORF gene was fused in frame with exon 5 of the CBP gene. In a reciprocal CBP-MORF transcript, exon 4 of the CBP gene was fused in frame with exon 16 of the MORF gene. This is the first reported case of t-MDS associated with t(10;16), and provides molecular evidence that the novel MORF-CBP and/or CBP-MORF fusion protein(s) might play an important role in the development of t-MDS.

KW - CREB binding protein gene

KW - Monocytic leukaemia zinc finger protein-related factor gene

KW - Therapy-related myelodysplastic syndrome

KW - Translocation (10;16)

UR - http://www.scopus.com/inward/record.url?scp=0037275494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037275494&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.2003.04059.x

DO - 10.1046/j.1365-2141.2003.04059.x

M3 - Article

C2 - 12542485

AN - SCOPUS:0037275494

VL - 120

SP - 271

EP - 273

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 2

ER -