A novel framework of circulatory equilibrium

Kazunori Uemura, Masaru Sugimachi, Toru Kawada, Atsunori Kamiya, Yintie Jin, Koji Kashihara, Kenji Sunagawa

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33 Citations (Scopus)

Abstract

A novel framework of circulatory equilibrium was developed by extending Guyton's original concept. In this framework, venous return (COV) for a given stressed volume (V) was characterized by a flat surface as a function of right atrial pressure (PRA) and left atrial pressure (PLA) as follows: COV = V/W - GSPRA - GPPLA, where W, GS, and GP denote linear parameters. In seven dogs under total heart bypass, COV, PRA, PLA, and V were varied to determine the three parameters in each animal with use of multivariate analysis. The coefficient of determination (r2 = 0.92-0.99) indicated the flatness of the venous return surface. The averaged surface was COV = V/0.129 - 19.61P RA - 3.49PLA. To examine the invariability of the surface parameters among animals, we predicted the circulatory equilibrium in response to changes in stressed volume in another 12 dogs under normal and heart failure conditions. This was achieved by equating the standard surface with the individually measured cardiac output (CO) curve. In this way, we could predict CO [y = 0.90x + 5.6, r2 = 0.95, standard error of the estimate (SEE) = 8.7 ml·min-1·kg-1], PRA (y = 0.96x, r2 = 0.98, SEE = 0.2 mmHg), and PLA (y = 0.89x + 0.5, r2 = 0.98, SEE = 0.8 mmHg) reasonably well. We conclude that the venous return surface accurately represents the venous return properties of the systemic and pulmonary circulations. The characteristics of the venous return surface are invariable enough among animals, making it possible to predict circulatory equilibrium, even if those characteristics are unknown in individual animals.

Original languageEnglish
Pages (from-to)H2376-H2385
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume286
Issue number6 55-6
DOIs
Publication statusPublished - Jun 1 2004
Externally publishedYes

Keywords

  • Cardiac output
  • Hemodynamics
  • Venous return

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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  • Cite this

    Uemura, K., Sugimachi, M., Kawada, T., Kamiya, A., Jin, Y., Kashihara, K., & Sunagawa, K. (2004). A novel framework of circulatory equilibrium. American Journal of Physiology - Heart and Circulatory Physiology, 286(6 55-6), H2376-H2385. https://doi.org/10.1152/ajpheart.00654.2003