A novel convergent approach to trans-fused polyether frameworks based on the reaction of vinylstannanes and triflates and its application to a synthetic study of the EFGH ring system of gambierol

Chie Kadowaki, Philip W.H. Chan, Isao Kadota, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

A new strategy for the convergent assembly of six-membered polycyclic ether ring fragments has been developed based upon the novel reaction between vinylstannanes with triflates in the presence of a strong base. The application of the present method has allowed for a synthetic study of the EFGH ring of gambierol to be achieved. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)5769-5772
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number30
DOIs
Publication statusPublished - Jul 22 2000
Externally publishedYes

Keywords

  • Coupling
  • Polycyclic ether
  • Triflate
  • Vinylstannane

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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