A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

Jlenia Guarnerio, Lourdes Maria Mendez, Noboru Asada, Archita Venugopal Menon, Jacqueline Fung, Kelsey Berry, Paul S. Frenette, Keisuke Ito, Pier Paolo Pandolfi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Disease recurrence after therapy, due to the persistence of resistant leukemic cells, represents a fundamental problem in the treatment of leukemia. Elucidating the mechanisms responsible for the maintenance of leukemic cells, before and after treatment, is therefore critical to identify curative modalities. It has become increasingly clear that cell-autonomous mechanisms are not solely responsible for leukemia maintenance. Here, we report a role for Pml in mesenchymal stem cells (MSCs) in supporting leukemic cells of both CML and AML. Mechanistically, we show that Pml regulates pro-inflammatory cytokines within MSCs, and that this function is critical in sustaining CML-KLS and AML ckit+ leukemic cells non-cell autonomously.

Original languageEnglish
Article number66
JournalNature Communications
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 1 2018
Externally publishedYes

Fingerprint

Emitter coupled logic circuits
leukemias
Stem cells
maintenance
Leukemia
Maintenance
cells
stem cells
Mesenchymal Stromal Cells
Cytokines
sustaining
therapy
Recurrence

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Guarnerio, J., Mendez, L. M., Asada, N., Menon, A. V., Fung, J., Berry, K., ... Pandolfi, P. P. (2018). A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche. Nature Communications, 9(1), [66]. https://doi.org/10.1038/s41467-017-02427-x

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche. / Guarnerio, Jlenia; Mendez, Lourdes Maria; Asada, Noboru; Menon, Archita Venugopal; Fung, Jacqueline; Berry, Kelsey; Frenette, Paul S.; Ito, Keisuke; Pandolfi, Pier Paolo.

In: Nature Communications, Vol. 9, No. 1, 66, 01.12.2018.

Research output: Contribution to journalArticle

Guarnerio, J, Mendez, LM, Asada, N, Menon, AV, Fung, J, Berry, K, Frenette, PS, Ito, K & Pandolfi, PP 2018, 'A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche', Nature Communications, vol. 9, no. 1, 66. https://doi.org/10.1038/s41467-017-02427-x
Guarnerio, Jlenia ; Mendez, Lourdes Maria ; Asada, Noboru ; Menon, Archita Venugopal ; Fung, Jacqueline ; Berry, Kelsey ; Frenette, Paul S. ; Ito, Keisuke ; Pandolfi, Pier Paolo. / A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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