Abstract
Partial nucleotide sequences in the tentative NS5 region of the hepatitis C viral genome obtained from patients with chronic hepatitis in Thailand were analyzed by reverse transcription followed by the polymerase chain reaction. Of ten samples studied, four showed low homologies to any known type of HCV: the homologies of the nucleotide sequences of these clones with HCV-J, -US, -K2a and -K2b were 66.5-69.1%, 66.5-68.2%, 61.2-64.1% and 64.4-66.2%, respectively, and the homologies of their deduced amino acids sequences were 71.7-75.2%, 71.7-75.2%, 69.0-72.6% and 69.9-73.5%, respectively. These four clones were classified a new distinct type of HCV, named HCV-T. Moreover, the nucleotide and amino acid sequence homologies of the four HCV-T clones showed that the HCV-T type could be classified into two genotypes, HCV-Ta and HCV-Tb.
| Original language | English |
|---|---|
| Pages (from-to) | 334-342 |
| Number of pages | 9 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 183 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 28 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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A new type of hepatitis C virus in patients in Thailand. / Mori, Shigehisa; Kato, Nobuyuki; Yagyu, Akiko; Tanaka, Torahiko; Ikeda, Yasuo; Petchclai, Bencha; Chiewsilp, Pimol; Kurimura, Takashi; Shimotohno, Kunitada.
In: Biochemical and Biophysical Research Communications, Vol. 183, No. 1, 28.02.1992, p. 334-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A new type of hepatitis C virus in patients in Thailand
AU - Mori, Shigehisa
AU - Kato, Nobuyuki
AU - Yagyu, Akiko
AU - Tanaka, Torahiko
AU - Ikeda, Yasuo
AU - Petchclai, Bencha
AU - Chiewsilp, Pimol
AU - Kurimura, Takashi
AU - Shimotohno, Kunitada
PY - 1992/2/28
Y1 - 1992/2/28
N2 - Partial nucleotide sequences in the tentative NS5 region of the hepatitis C viral genome obtained from patients with chronic hepatitis in Thailand were analyzed by reverse transcription followed by the polymerase chain reaction. Of ten samples studied, four showed low homologies to any known type of HCV: the homologies of the nucleotide sequences of these clones with HCV-J, -US, -K2a and -K2b were 66.5-69.1%, 66.5-68.2%, 61.2-64.1% and 64.4-66.2%, respectively, and the homologies of their deduced amino acids sequences were 71.7-75.2%, 71.7-75.2%, 69.0-72.6% and 69.9-73.5%, respectively. These four clones were classified a new distinct type of HCV, named HCV-T. Moreover, the nucleotide and amino acid sequence homologies of the four HCV-T clones showed that the HCV-T type could be classified into two genotypes, HCV-Ta and HCV-Tb.
AB - Partial nucleotide sequences in the tentative NS5 region of the hepatitis C viral genome obtained from patients with chronic hepatitis in Thailand were analyzed by reverse transcription followed by the polymerase chain reaction. Of ten samples studied, four showed low homologies to any known type of HCV: the homologies of the nucleotide sequences of these clones with HCV-J, -US, -K2a and -K2b were 66.5-69.1%, 66.5-68.2%, 61.2-64.1% and 64.4-66.2%, respectively, and the homologies of their deduced amino acids sequences were 71.7-75.2%, 71.7-75.2%, 69.0-72.6% and 69.9-73.5%, respectively. These four clones were classified a new distinct type of HCV, named HCV-T. Moreover, the nucleotide and amino acid sequence homologies of the four HCV-T clones showed that the HCV-T type could be classified into two genotypes, HCV-Ta and HCV-Tb.
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U2 - 10.1016/0006-291X(92)91648-A
DO - 10.1016/0006-291X(92)91648-A
M3 - Article
VL - 183
SP - 334
EP - 342
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -