A new taxane composed of two N-formyl rotamers from Taxus canadensis

Man Li Zhang, Mei Dong, Xiao Ning Li, Li Geng Li, Fançoise Sauriol, Chang Hong Huo, Qing Wen Shi, Yu Cheng Gu, Hiromasa Kiyota, Bin Cong

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


A taxane with an amino-side chain on C-5 was identified for the first time from rooted cuttings of the Canadian yew, Taxus canadensis. The structure was characterized as 7β,9α,10β,13α-tetraacetoxy-5α-[3′-(N-formyl-N-methylamino)-3′-phenylpropanoyl]oxytaxa-4(20),12-diene (1) on the basis of 1D-, 2D-NMR data, and HR-FABMS analyses. The spectra revealed that in CDCl3 solution 1 was composed of two rotamers (1a and 1b) in a ratio of approximately 2:1.

Original languageEnglish
Pages (from-to)3405-3408
Number of pages4
JournalTetrahedron Letters
Issue number21
Publication statusPublished - May 19 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'A new taxane composed of two N-formyl rotamers from Taxus canadensis'. Together they form a unique fingerprint.

Cite this