A new target for therapy in squamous cell carcinoma of the lung

Kadoaki Oohashi, William Pao

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Investigators report the identification of novel somatic mutations in the DDR2 kinase gene in squamous cell carcinoma of the lung. Cellular, biochemical, and human data suggest that tumor cells harboring DDR2 mutations have increased sensitivity to existing tyrosine kinase inhibitors, providing rationale for clinical trials of agents that inhibit DDR2 kinase in the disease.

Original languageEnglish
Pages (from-to)23-24
Number of pages2
JournalCancer Discovery
Volume1
Issue number1
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

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Squamous Cell Carcinoma
Lung
Mutation
Protein-Tyrosine Kinases
Research Personnel
Clinical Trials
Therapeutics
Genes
Neoplasms
Discoidin Domain Receptor 2

ASJC Scopus subject areas

  • Oncology

Cite this

A new target for therapy in squamous cell carcinoma of the lung. / Oohashi, Kadoaki; Pao, William.

In: Cancer Discovery, Vol. 1, No. 1, 06.2011, p. 23-24.

Research output: Contribution to journalArticle

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