A New Synthesis of Pyrimido[4,5-b]quinoline-2,4(1H,3H)diones (5-Deazaalloxazines) by Oxidative Cyclization of Aryl-bis (6-amino-1,3-dimethyluracil-5-yl) - methanes with Diethyl Azodicarboxylate

Fumio Yoneda, Fusako Takayama, Akira Koshiro

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Abstract

Treatment of aryl-bis (6-amino-l,3-dimethyluracil-5-yl) methanes, which were prepared by the condensation of 6-amino-1,3-dimethyluracil with aryl aldehydes, with diethyl azodicarboxylate in the presence of sulfolane led to the formation of the corresponding 1.3-dimethylpyrimido[4,5-b]quinoline-2,4(1H,3H)diones (1,3-dimethyl-5-deazaalloxazines).

Original languageEnglish
Pages (from-to)2507-2510
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume27
Issue number10
DOIs
Publication statusPublished - 1979
Externally publishedYes

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Keywords

  • 5-deazaalloxazine
  • bis(6-amino-l,3-dimethyluracil-5-yl)methane
  • diethyl azodicarboxylate
  • oxidative cyclization
  • pyrimido[4,5-b]quinoline

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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