A new strategy of reperfusion therapy in acute myocardial infarction: Usefulness of a simple and effective thrombus aspiration therapy using a Rescue™ percutaneous thrombectomy system

S. Kawano, Hiroshi Itoh, K. Iwakura, A. Okamura, Y. Inoue, A. Kato, K. Asano, M. Ikushima, K. Fujii, T. Fujii, M. Ueda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Although coronary angioplasty is effective in the treatment of acute myocardial infarction (AMI), distal coronary embolization originating from an intracoronary thrombus may attenuate the beneficial impact of reperfusion therapy. Coronary thrombectomy prior to angioplasty may reduce the embolic complications. Methods and Results: We evaluated the angiographic outcomes of 66 patients with AMI who underwent thrombus aspiration with a Rescue percutaneous thrombectomy system (Rescue) followed by adjunctive angioplasty. The Rescue catheter was able to pass the culprit lesion in 60 of the studied patients (91%). Visible thrombi were obtained in 57 patients (86%). On average, the aspirated thrombi weighed 10.4+/-14.7 mg. Histological examination revealed three types of thrombi (white, red and mixed thrombi). Although the following angioplasty was associated with the reduction of the distal embolization in 20 patients (33%), the intracoronary injection of vasodilators and the recurrent thrombus aspiration improved coronary flow in 10 patients. Final TIMI 3 flow was achieved in 47 patients (78%). Conclusions: Thrombus aspiration with Rescue can be a simple and effective reperfusion therapy, allowing for an initial strategy prior to angioplasty in the treatment of AMI. Furthermore, histological evaluation reveals the cellular components of the aspirated thrombus, which may enhance the better understanding of the pathophysiology of AMI.

Original languageEnglish
Pages (from-to)503-508
Number of pages6
JournalJapanese Journal of Interventional Cardiology
Volume16
Issue number6
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Thrombectomy
Reperfusion
Thrombosis
Myocardial Infarction
Angioplasty
Therapeutics
Vasodilator Agents
Catheters
Injections

Keywords

  • Coronary reperfusion
  • Distal embolization
  • Thrombectomy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

A new strategy of reperfusion therapy in acute myocardial infarction : Usefulness of a simple and effective thrombus aspiration therapy using a Rescue™ percutaneous thrombectomy system. / Kawano, S.; Itoh, Hiroshi; Iwakura, K.; Okamura, A.; Inoue, Y.; Kato, A.; Asano, K.; Ikushima, M.; Fujii, K.; Fujii, T.; Ueda, M.

In: Japanese Journal of Interventional Cardiology, Vol. 16, No. 6, 2001, p. 503-508.

Research output: Contribution to journalArticle

Kawano, S. ; Itoh, Hiroshi ; Iwakura, K. ; Okamura, A. ; Inoue, Y. ; Kato, A. ; Asano, K. ; Ikushima, M. ; Fujii, K. ; Fujii, T. ; Ueda, M. / A new strategy of reperfusion therapy in acute myocardial infarction : Usefulness of a simple and effective thrombus aspiration therapy using a Rescue™ percutaneous thrombectomy system. In: Japanese Journal of Interventional Cardiology. 2001 ; Vol. 16, No. 6. pp. 503-508.
@article{5fed9cdcdfa2446a8a703e8d0d31f37d,
title = "A new strategy of reperfusion therapy in acute myocardial infarction: Usefulness of a simple and effective thrombus aspiration therapy using a Rescue™ percutaneous thrombectomy system",
abstract = "Background: Although coronary angioplasty is effective in the treatment of acute myocardial infarction (AMI), distal coronary embolization originating from an intracoronary thrombus may attenuate the beneficial impact of reperfusion therapy. Coronary thrombectomy prior to angioplasty may reduce the embolic complications. Methods and Results: We evaluated the angiographic outcomes of 66 patients with AMI who underwent thrombus aspiration with a Rescue™ percutaneous thrombectomy system (Rescue) followed by adjunctive angioplasty. The Rescue catheter was able to pass the culprit lesion in 60 of the studied patients (91{\%}). Visible thrombi were obtained in 57 patients (86{\%}). On average, the aspirated thrombi weighed 10.4+/-14.7 mg. Histological examination revealed three types of thrombi (white, red and mixed thrombi). Although the following angioplasty was associated with the reduction of the distal embolization in 20 patients (33{\%}), the intracoronary injection of vasodilators and the recurrent thrombus aspiration improved coronary flow in 10 patients. Final TIMI 3 flow was achieved in 47 patients (78{\%}). Conclusions: Thrombus aspiration with Rescue can be a simple and effective reperfusion therapy, allowing for an initial strategy prior to angioplasty in the treatment of AMI. Furthermore, histological evaluation reveals the cellular components of the aspirated thrombus, which may enhance the better understanding of the pathophysiology of AMI.",
keywords = "Coronary reperfusion, Distal embolization, Thrombectomy",
author = "S. Kawano and Hiroshi Itoh and K. Iwakura and A. Okamura and Y. Inoue and A. Kato and K. Asano and M. Ikushima and K. Fujii and T. Fujii and M. Ueda",
year = "2001",
language = "English",
volume = "16",
pages = "503--508",
journal = "Japanese Journal of Interventional Cardiology",
issn = "0914-8922",
publisher = "Japanese Society of Interventional Cardiology",
number = "6",

}

TY - JOUR

T1 - A new strategy of reperfusion therapy in acute myocardial infarction

T2 - Usefulness of a simple and effective thrombus aspiration therapy using a Rescue™ percutaneous thrombectomy system

AU - Kawano, S.

AU - Itoh, Hiroshi

AU - Iwakura, K.

AU - Okamura, A.

AU - Inoue, Y.

AU - Kato, A.

AU - Asano, K.

AU - Ikushima, M.

AU - Fujii, K.

AU - Fujii, T.

AU - Ueda, M.

PY - 2001

Y1 - 2001

N2 - Background: Although coronary angioplasty is effective in the treatment of acute myocardial infarction (AMI), distal coronary embolization originating from an intracoronary thrombus may attenuate the beneficial impact of reperfusion therapy. Coronary thrombectomy prior to angioplasty may reduce the embolic complications. Methods and Results: We evaluated the angiographic outcomes of 66 patients with AMI who underwent thrombus aspiration with a Rescue™ percutaneous thrombectomy system (Rescue) followed by adjunctive angioplasty. The Rescue catheter was able to pass the culprit lesion in 60 of the studied patients (91%). Visible thrombi were obtained in 57 patients (86%). On average, the aspirated thrombi weighed 10.4+/-14.7 mg. Histological examination revealed three types of thrombi (white, red and mixed thrombi). Although the following angioplasty was associated with the reduction of the distal embolization in 20 patients (33%), the intracoronary injection of vasodilators and the recurrent thrombus aspiration improved coronary flow in 10 patients. Final TIMI 3 flow was achieved in 47 patients (78%). Conclusions: Thrombus aspiration with Rescue can be a simple and effective reperfusion therapy, allowing for an initial strategy prior to angioplasty in the treatment of AMI. Furthermore, histological evaluation reveals the cellular components of the aspirated thrombus, which may enhance the better understanding of the pathophysiology of AMI.

AB - Background: Although coronary angioplasty is effective in the treatment of acute myocardial infarction (AMI), distal coronary embolization originating from an intracoronary thrombus may attenuate the beneficial impact of reperfusion therapy. Coronary thrombectomy prior to angioplasty may reduce the embolic complications. Methods and Results: We evaluated the angiographic outcomes of 66 patients with AMI who underwent thrombus aspiration with a Rescue™ percutaneous thrombectomy system (Rescue) followed by adjunctive angioplasty. The Rescue catheter was able to pass the culprit lesion in 60 of the studied patients (91%). Visible thrombi were obtained in 57 patients (86%). On average, the aspirated thrombi weighed 10.4+/-14.7 mg. Histological examination revealed three types of thrombi (white, red and mixed thrombi). Although the following angioplasty was associated with the reduction of the distal embolization in 20 patients (33%), the intracoronary injection of vasodilators and the recurrent thrombus aspiration improved coronary flow in 10 patients. Final TIMI 3 flow was achieved in 47 patients (78%). Conclusions: Thrombus aspiration with Rescue can be a simple and effective reperfusion therapy, allowing for an initial strategy prior to angioplasty in the treatment of AMI. Furthermore, histological evaluation reveals the cellular components of the aspirated thrombus, which may enhance the better understanding of the pathophysiology of AMI.

KW - Coronary reperfusion

KW - Distal embolization

KW - Thrombectomy

UR - http://www.scopus.com/inward/record.url?scp=0035673141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035673141&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0035673141

VL - 16

SP - 503

EP - 508

JO - Japanese Journal of Interventional Cardiology

JF - Japanese Journal of Interventional Cardiology

SN - 0914-8922

IS - 6

ER -