A new screening method to diagnose coronary artery disease using multichannel magnetocardiogram and simple exercise

Hideaki Kanzaki, Satoshi Nakatani, Akihiko Kandori, Keiji Tsukada, Kunio Miyatake

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Magnetocardiography (MCG) is a non-contact mapping technique to record cardiac action currents. The Master's two-step electrocardiogram (ECG) test is a simple exercise method for screening coronary artery disease (CAD), but it is inadequate concerning the sensitivity. Our aim was to develop a new screening method using multichannel MCG instead of ECG. Methods: Thirty subjects (aged 54 ± 16 years, 27 males), 17 of whom had CAD confirmed by coronary angiography, underwent the Master's exercise ECG test. After the exercise, MCG signals were acquired every minute during recovery with a 64-channel MCG system (MC-6400, Hitachi Ltd). We integrated tangential components of the MCG signals within QRS (during 20, 40, 80, and 120 ms centering on R-wave peak) immediately after exercise (Iex) and 5 minutes after exercise (Irec). The exercise-induced change of currents [(Iex-Irec)/Irec] was determined and normalized for each channel, and the maximal change among 64 channels, maximal QRS integral change, was used as a diagnostic index for myocardial ischemia. Results: The maximal QRS integral change during 40 ms was significantly higher in the CAD group than in the control group (0.81 ± 0.51 vs. 0.36 ± 0.19, p <0.01). A sensitivity and specificity for predicting CAD by the change > 0.44 were 82% and 85%, respectively, yielding a diagnostic accuracy of 83%. The conventional Master's ECG test identified the CAD patients with a diagnostic accuracy of 63% (sensitivity 47%, specificity 85%). Conclusion: The Master's two-step exercise test with a 64-channel MCG system showed the high diagnostic accuracy, despite of non-contact recording and simple exercise. The magnetic field in the depolarization process has the potential to detect the subtle myocardial ischemia induced by exercise.

Original languageEnglish
Pages (from-to)124-132
Number of pages9
JournalBasic Research in Cardiology
Volume98
Issue number2
DOIs
Publication statusPublished - Mar 2003
Externally publishedYes

Fingerprint

Magnetocardiography
Coronary Artery Disease
Exercise
Exercise Test
Electrocardiography
Myocardial Ischemia
Magnetic Fields
Coronary Angiography
Sensitivity and Specificity
Control Groups

Keywords

  • Coronary artery disease
  • Magnetic field
  • Magnetocardiography
  • Myocardial ischemia
  • QRS complex

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

A new screening method to diagnose coronary artery disease using multichannel magnetocardiogram and simple exercise. / Kanzaki, Hideaki; Nakatani, Satoshi; Kandori, Akihiko; Tsukada, Keiji; Miyatake, Kunio.

In: Basic Research in Cardiology, Vol. 98, No. 2, 03.2003, p. 124-132.

Research output: Contribution to journalArticle

Kanzaki, Hideaki ; Nakatani, Satoshi ; Kandori, Akihiko ; Tsukada, Keiji ; Miyatake, Kunio. / A new screening method to diagnose coronary artery disease using multichannel magnetocardiogram and simple exercise. In: Basic Research in Cardiology. 2003 ; Vol. 98, No. 2. pp. 124-132.
@article{548e5fb4ccba45d5ac8e136a1c17a39f,
title = "A new screening method to diagnose coronary artery disease using multichannel magnetocardiogram and simple exercise",
abstract = "Background: Magnetocardiography (MCG) is a non-contact mapping technique to record cardiac action currents. The Master's two-step electrocardiogram (ECG) test is a simple exercise method for screening coronary artery disease (CAD), but it is inadequate concerning the sensitivity. Our aim was to develop a new screening method using multichannel MCG instead of ECG. Methods: Thirty subjects (aged 54 ± 16 years, 27 males), 17 of whom had CAD confirmed by coronary angiography, underwent the Master's exercise ECG test. After the exercise, MCG signals were acquired every minute during recovery with a 64-channel MCG system (MC-6400, Hitachi Ltd). We integrated tangential components of the MCG signals within QRS (during 20, 40, 80, and 120 ms centering on R-wave peak) immediately after exercise (Iex) and 5 minutes after exercise (Irec). The exercise-induced change of currents [(Iex-Irec)/Irec] was determined and normalized for each channel, and the maximal change among 64 channels, maximal QRS integral change, was used as a diagnostic index for myocardial ischemia. Results: The maximal QRS integral change during 40 ms was significantly higher in the CAD group than in the control group (0.81 ± 0.51 vs. 0.36 ± 0.19, p <0.01). A sensitivity and specificity for predicting CAD by the change > 0.44 were 82{\%} and 85{\%}, respectively, yielding a diagnostic accuracy of 83{\%}. The conventional Master's ECG test identified the CAD patients with a diagnostic accuracy of 63{\%} (sensitivity 47{\%}, specificity 85{\%}). Conclusion: The Master's two-step exercise test with a 64-channel MCG system showed the high diagnostic accuracy, despite of non-contact recording and simple exercise. The magnetic field in the depolarization process has the potential to detect the subtle myocardial ischemia induced by exercise.",
keywords = "Coronary artery disease, Magnetic field, Magnetocardiography, Myocardial ischemia, QRS complex",
author = "Hideaki Kanzaki and Satoshi Nakatani and Akihiko Kandori and Keiji Tsukada and Kunio Miyatake",
year = "2003",
month = "3",
doi = "10.1007/s00395-003-0392-0",
language = "English",
volume = "98",
pages = "124--132",
journal = "Basic Research in Cardiology",
issn = "0300-8428",
publisher = "D. Steinkopff-Verlag",
number = "2",

}

TY - JOUR

T1 - A new screening method to diagnose coronary artery disease using multichannel magnetocardiogram and simple exercise

AU - Kanzaki, Hideaki

AU - Nakatani, Satoshi

AU - Kandori, Akihiko

AU - Tsukada, Keiji

AU - Miyatake, Kunio

PY - 2003/3

Y1 - 2003/3

N2 - Background: Magnetocardiography (MCG) is a non-contact mapping technique to record cardiac action currents. The Master's two-step electrocardiogram (ECG) test is a simple exercise method for screening coronary artery disease (CAD), but it is inadequate concerning the sensitivity. Our aim was to develop a new screening method using multichannel MCG instead of ECG. Methods: Thirty subjects (aged 54 ± 16 years, 27 males), 17 of whom had CAD confirmed by coronary angiography, underwent the Master's exercise ECG test. After the exercise, MCG signals were acquired every minute during recovery with a 64-channel MCG system (MC-6400, Hitachi Ltd). We integrated tangential components of the MCG signals within QRS (during 20, 40, 80, and 120 ms centering on R-wave peak) immediately after exercise (Iex) and 5 minutes after exercise (Irec). The exercise-induced change of currents [(Iex-Irec)/Irec] was determined and normalized for each channel, and the maximal change among 64 channels, maximal QRS integral change, was used as a diagnostic index for myocardial ischemia. Results: The maximal QRS integral change during 40 ms was significantly higher in the CAD group than in the control group (0.81 ± 0.51 vs. 0.36 ± 0.19, p <0.01). A sensitivity and specificity for predicting CAD by the change > 0.44 were 82% and 85%, respectively, yielding a diagnostic accuracy of 83%. The conventional Master's ECG test identified the CAD patients with a diagnostic accuracy of 63% (sensitivity 47%, specificity 85%). Conclusion: The Master's two-step exercise test with a 64-channel MCG system showed the high diagnostic accuracy, despite of non-contact recording and simple exercise. The magnetic field in the depolarization process has the potential to detect the subtle myocardial ischemia induced by exercise.

AB - Background: Magnetocardiography (MCG) is a non-contact mapping technique to record cardiac action currents. The Master's two-step electrocardiogram (ECG) test is a simple exercise method for screening coronary artery disease (CAD), but it is inadequate concerning the sensitivity. Our aim was to develop a new screening method using multichannel MCG instead of ECG. Methods: Thirty subjects (aged 54 ± 16 years, 27 males), 17 of whom had CAD confirmed by coronary angiography, underwent the Master's exercise ECG test. After the exercise, MCG signals were acquired every minute during recovery with a 64-channel MCG system (MC-6400, Hitachi Ltd). We integrated tangential components of the MCG signals within QRS (during 20, 40, 80, and 120 ms centering on R-wave peak) immediately after exercise (Iex) and 5 minutes after exercise (Irec). The exercise-induced change of currents [(Iex-Irec)/Irec] was determined and normalized for each channel, and the maximal change among 64 channels, maximal QRS integral change, was used as a diagnostic index for myocardial ischemia. Results: The maximal QRS integral change during 40 ms was significantly higher in the CAD group than in the control group (0.81 ± 0.51 vs. 0.36 ± 0.19, p <0.01). A sensitivity and specificity for predicting CAD by the change > 0.44 were 82% and 85%, respectively, yielding a diagnostic accuracy of 83%. The conventional Master's ECG test identified the CAD patients with a diagnostic accuracy of 63% (sensitivity 47%, specificity 85%). Conclusion: The Master's two-step exercise test with a 64-channel MCG system showed the high diagnostic accuracy, despite of non-contact recording and simple exercise. The magnetic field in the depolarization process has the potential to detect the subtle myocardial ischemia induced by exercise.

KW - Coronary artery disease

KW - Magnetic field

KW - Magnetocardiography

KW - Myocardial ischemia

KW - QRS complex

UR - http://www.scopus.com/inward/record.url?scp=0037343941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037343941&partnerID=8YFLogxK

U2 - 10.1007/s00395-003-0392-0

DO - 10.1007/s00395-003-0392-0

M3 - Article

C2 - 12607134

AN - SCOPUS:0037343941

VL - 98

SP - 124

EP - 132

JO - Basic Research in Cardiology

JF - Basic Research in Cardiology

SN - 0300-8428

IS - 2

ER -