A new route for preparation of 5-deoxy-5-(hydroxyphosphinyl)-D-mannopyranose and -L-gulopyranose derivatives

Tadashi Hanaya, Hiroshi Yamamoto

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    Starting from methyl 2,3-O-isopropylidene-α-D-mannofuranoside (5), methyl 6-O-benzyl-2,3-O-isopropylidene-α-D-lyxo-hexofuranosid-5-ulose (12) was prepared in three steps. The addition reaction of dimethyl phosphonate to 12, followed by deoxygenation of 5-OH group, provided the 5-deoxy-5-dimethoxyphosphinyl-α-D-mannofuranoside derivative 15a and the β-L-gulofuranoside isomer 15b. Reduction of 15a and 15b with sodium dihydrobis(2-methoxyethoxy)aluminate, followed by the action of HCl and then H2O2, afforded the D-mannopyranose (17) and L-gulopyranose analog 21, each having a phosphinyl group in the hemiacetal ring. These were converted to the corresponding 1,2,3,4,6-penta-O-acetyl-5-methoxyphosphinyl derivatives 19 and 23, respectively, structures and conformations (4C1 or 1C4, resp.) of which were established by 1H-NMR spectroscopy.

    Original languageEnglish
    Pages (from-to)2608-2618
    Number of pages11
    JournalHelvetica Chimica Acta
    Issue number9
    Publication statusPublished - Oct 29 2002

    ASJC Scopus subject areas

    • Catalysis
    • Biochemistry
    • Drug Discovery
    • Physical and Theoretical Chemistry
    • Organic Chemistry
    • Inorganic Chemistry


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