A new taxane with an amino side chain on C-5 and a new 11(15→1) abeotaxane having a tetrahydrofuran ring along carbon atoms C-2, C-3, C-4, C-20 identified for the first time from the needles of the Canadian yew, Taxus canadensis. Their structures were characterized as 2α,7β,9α, 10β,13-pentaacetoxy-11β-hydroxy-5α-(2′-hydroxy,3′-N, N-dimethylamino-3′-phenyl)-propionyloxytaxa-4(20),12-diene (1) and 13α,20β-diacetoxy-5α,7β,9α,10β- tetrahydroxy2α,20-epoxy-11(15→1)abeotaxa-11,15-diene (2) on the basis of ID, 2D NMR spectroscopy and high-resolution FABMS analysis. Taxane 1 contains a rare C-12, C-13 double bond and a basic side chain, while taxane 2 bears a rare isopropenyl group at C-1.
|Number of pages||7|
|Journal||Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences|
|Publication status||Published - Aug 1 2008|
- Taxus canadensis
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