### Abstract

In recent years, magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) has seen wide clinical use, such as for early detection of cerebrovascular diseases and whole body screening for tumors. The apparent diffusion coefficient (ADC) standard phantom, which mimics the ADC values of several lesions in the body, is indispensable for the development of new pulse sequences for DWI, such as diffusion-weighted whole-body imaging with background body-signal suppression (DWIBS). However, information on the ADC values of the previously reported ADC standard phantoms is limited, because these phantoms were made using only a few different materials at a limited range of concentrations, and the ADC values were measured only at certain temperatures. It has been considered difficult, if not impossible, to create a phantom that provides arbitrary ADC values, because it is difficult to calculate the concentrations of the materials and the temperature at ADC measurement. In this study, we used polyethylene glycol (PEG) as a phantom material, and developed an empirical formula to calculate the PEG concentration at any measurement temperature to obtain arbitrary ADC values of the phantom. DWI images of phantoms made using seven different PEG concentrations were taken under heating from 17 to 46°C at 1°C intervals. Using ADC values calculated from these DWI images, we developed two empirical formulas: i) an empirical formula to calculate the ADC values of phantoms made using any PEG concentration at any measurement temperature; and ii) an empirical formula to calculate PEG concentrations to obtain arbitrary ADC values at any measurement temperature. We inspected the accuracy of these empirical formulas by newly made PEG phantoms. A comparison between the ADC values calculated with the empirical formulas and the measured ADC values confirmed the high accuracy of these formulas. PEG phantoms are safe, inexpensive and easy to make, compared with the previously reported ADC standard phantoms. Our empirical formulas enable us to calculate PEG concentrations that provide arbitrary ADC values at any measurement temperature. The empirical formulas could be used within a range of ADC values from 0.37x10^{-3} to 3.67x10^{-3} mm^{2}/s, PEG concentrations from 0 to 120 mM, and measurement temperatures from 18 to 45°C. Using these formulas, it would be possible to make standard phantoms that mimic the ADC values of any clinical lesions. The PEG phantom might thus be an excellent new ADC standard phantom for MRI with DWI.

Original language | English |
---|---|

Pages (from-to) | 893-900 |

Number of pages | 8 |

Journal | International Journal of Oncology |

Volume | 35 |

Issue number | 4 |

DOIs | |

Publication status | Published - Oct 2009 |

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### Keywords

- Apparent diffusion coefficient value
- Diffusion-weighted imaging
- Magnetic resonance imaging
- Polyethylene glycol
- Standard phantom

### ASJC Scopus subject areas

- Cancer Research
- Oncology

### Cite this

*International Journal of Oncology*,

*35*(4), 893-900. https://doi.org/10.3892/ijo-00000404

**A new phantom using polyethylene glycol as an apparent diffusion coefficient standard for MR imaging.** / Matsuya, Ryohei; Kuroda, Masahiro; Matsumoto, Yoshitsugu; Kato, Hirokazu; Matsuzaki, Hidenobu; Asaumi, Jun-Ichi; Murakami, Jun; Katashima, Kazunori; Ashida, Masakazu; Sasaki, Takanori; Sei, Tetsuro; Himei, Kengo; Katsui, Kuniaki; Katayama, Norihisa; Takemoto, Mitsuhiro; Kanazawa, Susumu; Mimura, Seiichi; Oono, Seiichiro; Kitayama, Takuichi; Tahara, Seiji; Inamura, Keiji.

Research output: Contribution to journal › Article

*International Journal of Oncology*, vol. 35, no. 4, pp. 893-900. https://doi.org/10.3892/ijo-00000404

}

TY - JOUR

T1 - A new phantom using polyethylene glycol as an apparent diffusion coefficient standard for MR imaging

AU - Matsuya, Ryohei

AU - Kuroda, Masahiro

AU - Matsumoto, Yoshitsugu

AU - Kato, Hirokazu

AU - Matsuzaki, Hidenobu

AU - Asaumi, Jun-Ichi

AU - Murakami, Jun

AU - Katashima, Kazunori

AU - Ashida, Masakazu

AU - Sasaki, Takanori

AU - Sei, Tetsuro

AU - Himei, Kengo

AU - Katsui, Kuniaki

AU - Katayama, Norihisa

AU - Takemoto, Mitsuhiro

AU - Kanazawa, Susumu

AU - Mimura, Seiichi

AU - Oono, Seiichiro

AU - Kitayama, Takuichi

AU - Tahara, Seiji

AU - Inamura, Keiji

PY - 2009/10

Y1 - 2009/10

N2 - In recent years, magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) has seen wide clinical use, such as for early detection of cerebrovascular diseases and whole body screening for tumors. The apparent diffusion coefficient (ADC) standard phantom, which mimics the ADC values of several lesions in the body, is indispensable for the development of new pulse sequences for DWI, such as diffusion-weighted whole-body imaging with background body-signal suppression (DWIBS). However, information on the ADC values of the previously reported ADC standard phantoms is limited, because these phantoms were made using only a few different materials at a limited range of concentrations, and the ADC values were measured only at certain temperatures. It has been considered difficult, if not impossible, to create a phantom that provides arbitrary ADC values, because it is difficult to calculate the concentrations of the materials and the temperature at ADC measurement. In this study, we used polyethylene glycol (PEG) as a phantom material, and developed an empirical formula to calculate the PEG concentration at any measurement temperature to obtain arbitrary ADC values of the phantom. DWI images of phantoms made using seven different PEG concentrations were taken under heating from 17 to 46°C at 1°C intervals. Using ADC values calculated from these DWI images, we developed two empirical formulas: i) an empirical formula to calculate the ADC values of phantoms made using any PEG concentration at any measurement temperature; and ii) an empirical formula to calculate PEG concentrations to obtain arbitrary ADC values at any measurement temperature. We inspected the accuracy of these empirical formulas by newly made PEG phantoms. A comparison between the ADC values calculated with the empirical formulas and the measured ADC values confirmed the high accuracy of these formulas. PEG phantoms are safe, inexpensive and easy to make, compared with the previously reported ADC standard phantoms. Our empirical formulas enable us to calculate PEG concentrations that provide arbitrary ADC values at any measurement temperature. The empirical formulas could be used within a range of ADC values from 0.37x10-3 to 3.67x10-3 mm2/s, PEG concentrations from 0 to 120 mM, and measurement temperatures from 18 to 45°C. Using these formulas, it would be possible to make standard phantoms that mimic the ADC values of any clinical lesions. The PEG phantom might thus be an excellent new ADC standard phantom for MRI with DWI.

AB - In recent years, magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) has seen wide clinical use, such as for early detection of cerebrovascular diseases and whole body screening for tumors. The apparent diffusion coefficient (ADC) standard phantom, which mimics the ADC values of several lesions in the body, is indispensable for the development of new pulse sequences for DWI, such as diffusion-weighted whole-body imaging with background body-signal suppression (DWIBS). However, information on the ADC values of the previously reported ADC standard phantoms is limited, because these phantoms were made using only a few different materials at a limited range of concentrations, and the ADC values were measured only at certain temperatures. It has been considered difficult, if not impossible, to create a phantom that provides arbitrary ADC values, because it is difficult to calculate the concentrations of the materials and the temperature at ADC measurement. In this study, we used polyethylene glycol (PEG) as a phantom material, and developed an empirical formula to calculate the PEG concentration at any measurement temperature to obtain arbitrary ADC values of the phantom. DWI images of phantoms made using seven different PEG concentrations were taken under heating from 17 to 46°C at 1°C intervals. Using ADC values calculated from these DWI images, we developed two empirical formulas: i) an empirical formula to calculate the ADC values of phantoms made using any PEG concentration at any measurement temperature; and ii) an empirical formula to calculate PEG concentrations to obtain arbitrary ADC values at any measurement temperature. We inspected the accuracy of these empirical formulas by newly made PEG phantoms. A comparison between the ADC values calculated with the empirical formulas and the measured ADC values confirmed the high accuracy of these formulas. PEG phantoms are safe, inexpensive and easy to make, compared with the previously reported ADC standard phantoms. Our empirical formulas enable us to calculate PEG concentrations that provide arbitrary ADC values at any measurement temperature. The empirical formulas could be used within a range of ADC values from 0.37x10-3 to 3.67x10-3 mm2/s, PEG concentrations from 0 to 120 mM, and measurement temperatures from 18 to 45°C. Using these formulas, it would be possible to make standard phantoms that mimic the ADC values of any clinical lesions. The PEG phantom might thus be an excellent new ADC standard phantom for MRI with DWI.

KW - Apparent diffusion coefficient value

KW - Diffusion-weighted imaging

KW - Magnetic resonance imaging

KW - Polyethylene glycol

KW - Standard phantom

UR - http://www.scopus.com/inward/record.url?scp=70449434533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70449434533&partnerID=8YFLogxK

U2 - 10.3892/ijo-00000404

DO - 10.3892/ijo-00000404

M3 - Article

C2 - 19724927

AN - SCOPUS:70449434533

VL - 35

SP - 893

EP - 900

JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

IS - 4

ER -