A new model of allergic rhinitis in rats by topical sensitization and evaluation of H1-receptor antagonists

Yukio Sugimoto, Etsuko Kawamoto, Zhong Chen, Chiaki Kamei

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

An animal model of chronic allergic rhinitis was developed by repeated local booster sensitization into the nasal cavity in sensitized rats. The severity of allergic rhinitis was assessed by determining the extent of two markers of nasal allergic symptoms (sneezing and nasal rubbing) after antigen challenge. The number of incidents of sneezing and nasal rubbing was markedly increased during intranasal instillation of antigen in sensitized rats. The PCA titers were also markedly elevated by intranasal sensitization. Some histamine H1-receptor antagonists such as chlorpheniramine, ketotifen, astemizole and epinastine inhibited the increase in antigen-induced nasal symptoms in a dose-related manner. Nasal rubbing was more potently inhibited by H1-receptor antagonists than sneezing.In conclusion, we developed a chronic allergic rhinitis model showing nasal symptoms in rats, and this model may be useful for evaluating the effects of drugs on allergic rhinitis. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalImmunopharmacology
Volume48
Issue number1
DOIs
Publication statusPublished - Jun 1 2000

Keywords

  • Allergic rhinitis
  • Histamine H-receptor antagonist
  • Nasal rubbing
  • Sneezing

ASJC Scopus subject areas

  • Pharmacology

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