A new method for the stereoselective construction of angular methyl group of fuzed cyclic ethers

Isao Kadota, Takayuki Kishi, Yuka Fujisawa, Yuji Yamagami, Hiroyoshi Takamura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A convenient method for the stereoselective construction of angular methyl group of fuzed cyclic ethers is described. Reactions of mixed thioacetals with Me2Zn/Zn(OTf)2 afforded the corresponding methylated products in good yields. Various protective groups such as MOM ether, benzylidene acetal, TBS ether, and pivaloyl group were stable under the reaction conditions.

Original languageEnglish
Pages (from-to)3960-3961
Number of pages2
JournalTetrahedron Letters
Volume51
Issue number30
DOIs
Publication statusPublished - Jul 28 2010

Keywords

  • Angular methyl group
  • Fuzed cyclic ethers
  • Marine polycyclic ethers
  • Mixed thioacetals

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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