New syntheses of 2-(alkylamino)benzoxazoles (III) and 3-alkyI-2-(alkylimino)benzoxazolines (IV) were developed. Various compounds III were obtained by the reactions of 2-(methylthio)benzoxazole with amines. In the alkylation of 2-(monoalkylamino)benzoxazoles, the use of a base as a catalyst was found to be important for the selective preparation of 2-(N, N-dialkylamino)benzoxazoles; in the absence of base, IV was obtained. On the other hand, alkylation of N, N ′-dialkyl-N-(2-hydroxyphenyl)thioureas resulted in the development of another method for the preparation of IV.
- N, N'-dialkyl-N-(2-hydroxyphenyl)thiourea
ASJC Scopus subject areas
- Drug Discovery