Abstract
The hydrolysis of racemic butyl 2-(4-substituted phenoxy)propionates having various substituents catalyzed by lipase MY from Candida rugosa was achieved in di-isopropyl ether containing 0.75% (v/v) of 2.4 M LiCl or 1.2 M MgCl2 aqueous solution. Water molecules hydrated to the metal ion in isopropyl ether acted as a nucleophile to cause the hydrolysis of these esters as with water alone. Metal ions used significantly enhanced their enantioselectivities by 100-fold or above, as compared with the ordinary reaction media.
Original language | English |
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Pages (from-to) | 1169-1171 |
Number of pages | 3 |
Journal | Biotechnology Letters |
Volume | 22 |
Issue number | 14 |
DOIs | |
Publication status | Published - Sep 19 2000 |
Externally published | Yes |
Keywords
- Enantioselectivity
- Hydrolysis
- Lipase
- Metal ion
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Applied Microbiology and Biotechnology