A new efficient method for the generation of F-alkyl ketone metal enolates by using copper(II) bromide-lithium aluminium hydride reagent and their aldol reaction with carbonyl compounds

1-Substituted F-1-alkenyl phosphates, readily prepared from F-alkyl ketones and sodium diethyl phosphite, were treated with copper(II) bromide-lithium aluminium hydride reagent at -30 °C to generate in situ F-alkyl ketone aluminium enolates, which underwent the aldol reaction with various aldehydes to give the corresponding α-fluoro-α-F-alkyl β-hydroxy ketones in fairly good to excellent yields.