1-Substituted F-1-alkenyl phosphates, readily prepared from F-alkyl ketones and sodium diethyl phosphite, were treated with copper(II) bromide-lithium aluminium hydride reagent at -30 °C to generate in situ F-alkyl ketone aluminium enolates, which underwent the aldol reaction with various aldehydes to give the corresponding α-fluoro-α-F-alkyl β-hydroxy ketones in fairly good to excellent yields.
|Number of pages||4|
|Publication status||Published - 1987|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry