A new cell-permeable peptide allows successful allogeneic islet transplantation in mice

Hirofumi Noguchi, Masayuki Matsushita, Teru Okitsu, Akiyoshi Moriwaki, Kazuhito Tomizawa, Sunghyun Kang, Sheng Tian Li, Naoya Kobayashi, Shinichi Matsumoto, Koich Tanaka, Noriaki Tanaka, Hideki Matsui

Research output: Contribution to journalArticlepeer-review

219 Citations (Scopus)

Abstract

Calcineurin inhibitors such as cyclosporine A and FK506 have been used for transplant therapy and treatment of autoimmune diseases. However, the inhibition of calcineurin outside the immune system has a number of side effects, including hyperglycemia. In the search for safer drugs, we developed a cell-permeable inhibitor of NFAT (nuclear factor of activated T cells) using the polyarginine peptide delivery system. This peptide provided immunosuppression for fully mismatched islet allografts in mice. In addition, it did not affect insulin secretion, whereas FK506 caused a dose-dependent decrease in insulin secretion. Cell-permeable peptides can thus provide a new strategy for drug development and may eventually be useful clinically.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalNature Medicine
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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