A new biosensing by Dielectric Dispersion Analysis of interaction between lipid membrane of liposome and target biomolecules up to 20 GHz range

Keisuke Takada, Kaoru Yamashita, Minoru Noda, Toshinori Shimanouchi, Hiroshi Umakoshi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

This paper reports, firstly, that it was newly found by our specific Dielectric Dispersion Analysis (DDA) that plural type of bound water with different relaxation frequencies exist in a suspension of liposome of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). Secondly, we observe that the interaction between the liposome and a specific target biomolecule depends on the type of target molecules (we used a protein of carbonic anhydrase from bovine (CAB) and/or cholesterol, respectively), leading to the change in dielectric relaxation at different relaxation frequency of bound water. It is finally concluded that the developed DDA method allows us to acquire the quantitative information with respect to bound water to liposomes, which gives novel physical insight on interaction between liposomes and target biomolecules (especially, protein).

Original languageEnglish
Title of host publicationIEEE SENSORS 2012 - Proceedings
DOIs
Publication statusPublished - Dec 1 2012
Externally publishedYes
Event11th IEEE SENSORS 2012 Conference - Taipei, Taiwan, Province of China
Duration: Oct 28 2012Oct 31 2012

Publication series

NameProceedings of IEEE Sensors

Other

Other11th IEEE SENSORS 2012 Conference
CountryTaiwan, Province of China
CityTaipei
Period10/28/1210/31/12

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'A new biosensing by Dielectric Dispersion Analysis of interaction between lipid membrane of liposome and target biomolecules up to 20 GHz range'. Together they form a unique fingerprint.

  • Cite this

    Takada, K., Yamashita, K., Noda, M., Shimanouchi, T., & Umakoshi, H. (2012). A new biosensing by Dielectric Dispersion Analysis of interaction between lipid membrane of liposome and target biomolecules up to 20 GHz range. In IEEE SENSORS 2012 - Proceedings [6411071] (Proceedings of IEEE Sensors). https://doi.org/10.1109/ICSENS.2012.6411071