A new alkaloid taxane composed of two N-formyl rotamers from the rooted cuttings of Taxus canadensis

Hong Zhen Zhang, Yu Fang Wang, Man Li Zhang, Mei Dong, Chang Hong Huo, Francoise Sauriol, Qing Wen Shi, Yu Cheng Gu, Hui Lan Wang, Hiromasa Kiyota

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6 Citations (Scopus)

Abstract

A taxane with an amino-side chain on C-5 was identified for the first time from rooted cuttings of the Canadian yew, Taxus canadensis. The structure was characterized as 2α,10β,13α-triacetoxy-5α-[3'-(N-formyl- Nmethylamino)-3'-phenylpropanoyloxy]taxa-4(20),12-dien-9α-ol (1) on the basis of 1D and 2D NMR data and HR-FAB-MS analyses. The spectra revealed that in CDCl3 solution 1 was composed of two rotamers (1a and 1b) in a ratio of approximately 1:1.

Original languageEnglish
Pages (from-to)1035-1038
Number of pages4
JournalChemistry of Natural Compounds
Volume48
Issue number6
DOIs
Publication statusPublished - Jan 1 2013

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Keywords

  • Taxaceae
  • Taxus canadensis
  • alkaloid
  • metabolites
  • taxane
  • yew

ASJC Scopus subject areas

  • Plant Science

Cite this

Zhang, H. Z., Wang, Y. F., Zhang, M. L., Dong, M., Huo, C. H., Sauriol, F., Shi, Q. W., Gu, Y. C., Wang, H. L., & Kiyota, H. (2013). A new alkaloid taxane composed of two N-formyl rotamers from the rooted cuttings of Taxus canadensis. Chemistry of Natural Compounds, 48(6), 1035-1038. https://doi.org/10.1007/s10600-013-0458-7